Parental Occupational Paint Exposure and Risk of Childhood Leukemia in the Offspring: Findings From the Childhood Leukemia International Consortium
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Purpose. It has been suggested that parental occupational paint exposure around the time of conception or pregnancy increases the risk of childhood leukemia in the offspring.Methods. We obtained individual level data from 13 case–control studies participating in the Childhood Leukemia International Consortium. Occupational data were harmonized to a compatible format. Meta-analyses of studyspecific odds ratios (ORs) were undertaken, as well as pooled analyses of individual data using unconditional logistic regression.Results. Using individual data from fathers of 8,185 cases and 14,210 controls, the pooled OR for paternal exposure around conception and risk of acute lymphoblastic leukemia (ALL) was 0.93 [95 % confidence interval (CI) 0.76, 1.14]. Analysis of data from 8,156 ALL case mothers and 14,568 control mothers produced a pooled OR of 0.81 (95 % CI 0.39, 1.68) for exposure during pregnancy. Foracute myeloid leukemia (AML), the pooled ORs for paternal and maternal exposure were 0.96 (95 % CI 0.65, 1.41) and 1.31 (95 % CI 0.38, 4.47), respectively, based on data from 1,231 case and 11,392 control fathers and 1,329 case and 12,141 control mothers. Heterogeneity among the individual studies ranged from low to modest.Conclusions. Null findings for paternal exposure for both ALL and AML are consistent with previous reports. Despite the large sample size, results for maternal exposure to paints in pregnancy were based on small numbers of exposed. Overall, we found no evidence that parental occupational exposure to paints increases the risk of leukemia in the offspring, but further data on home exposure are needed.
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Home paint exposures and risk of childhood acute lymphoblastic leukemia: findings from the Childhood Leukemia International ConsortiumBailey, H.; Metayer, C.; Milne, E.; Petridou, E.; Infante-Rivard, C.; Spector, L.; Clavel, J.; Dockerty, J.; Zhang, L.; Armstrong, B.; Rudant, J.; Fritschi, Lin; Amigou, A.; Hatzipantelis, E.; Kang, A.; Stiakaki, E.; Schüz, J. (2015)Purpose: It has been suggested that home paint exposure increases the risk of childhood acute lymphoblastic leukemia (ALL). Methods: We obtained individual level data from eight case–control studies participating in the ...
Home pesticide exposures and risk of childhood leukemia: Findings from the childhood leukemia international consortiumBailey, H.; Infante-Rivard, C.; Metayer, C.; Clavel, J.; Lightfoot, T.; Kaatsch, P.; Roman, E.; Magnani, C.; Spector, L.; Th Petridou, E.; Milne, E.; Dockerty, J.; Miligi, L.; Armstrong, B.; Rudant, J.; Fritschi, Lin; Simpson, J.; Zhang, L.; Rondelli, R.; Baka, M.; Orsi, L.; Moschovi, M.; Kang, A.; Schüz, J. (2015)© 2015 UICC. Some previous studies have suggested that home pesticide exposure before birth and during a child's early years may increase the risk of childhood leukemia. To further investigate this, we pooled individual ...
Parental Occupational Pesticide Exposure and the Risk of Childhood Leukemia in the Offspring: Findings From the Childhood Leukemia International ConsortiumBailey, H.; Fritschi, Lin; Infante-Rivard, C.; Glass, D.; Miligi, L.; Dockerty, J.; Lightfoot, T.; Clavel, J.; Roman, E.; Spector, L.; Kaatsch, P.; Metayer, C.; Magnani, C.; Milne, Elizabeth; Polychronopoulou, S.; Simpson, J.; Rudant, J.; Sidi, V.; Rondelli, R.; Orsi, L.; Kang, A.; Petridou, E.; Schuz, J. (2014)Maternal occupational pesticide exposure during pregnancy and/or paternal occupational pesticide exposure around conception have been suggested to increase risk of leukemia in the offspring. With a view to providing insight ...