Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Calcium antagonists use and its association with lower urinary tract symptoms: A cross-sectional study

    191865_91623_Elhebir_PLOS_One_2013.pdf (2.226Mb)
    Access Status
    Open access
    Authors
    Elhebir, Elsamaul
    Hughes, Jeffery
    Hilmi, Samantha
    Date
    2013
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Elhebir, Elsamaul S. and Hughes, Jeffery D. and Hilmi, Samantha C. 2013. Calcium antagonists use and its association with lower urinary tract symptoms: A cross-sectional study. PLoS ONE 8 (6): pp. 1-7.
    Source Title
    PLoS ONE
    DOI
    10.1371/journal.pone.0066708
    ISSN
    19326203
    URI
    http://hdl.handle.net/20.500.11937/31069
    Collection
    • Curtin Research Publications
    Abstract

    Background Lower urinary tract symptoms (LUTS) have been reported amongst the side effects of calcium antagonists (CA). CAs act on the bladder by affecting the ability of the detrusor muscle to create enough contractile force to overcome obstruction to normal voiding. We aimed to determine the relationship between CA use and LUTS in general medical inpatients. Methods and Findings In this cross-sectional study we recruited 278 medical inpatients (including 85 CA users) aged ≥40 (72.1±13.7) years. LUTS was assessed using the International Prostate Symptoms Score (IPSS) questionnaire. A Logistic regression model using a ‘backwards-elimination’ strategy was used to identify variables associated with LUTS and for calculating the adjusted odds ratios and the 95% confidence intervals (CI). After adjusting for other risk factors and drugs, patients on amlodipine/nifedipine and diltiazem/verapamil (compared to non-users) were more likely to suffer from severe LUTS [Males: 12.45(CI: 1.57–98.63) and Females: 7.75(CI: 0.94–63.94)] and moderate-to-severe LUTS [Males: 17.43(CI: 2•26–134.39) and Females: 47.8(CI: 6.22–367.37)]. Patients on felodipine/lercanidipine were less likely to suffer from either severe or moderate-to-severe LUTS. Further, 19 (22.4%) CA-users were on treatment for LUTS compared to 18 (9.3%) of the non-users group, p = 0.003. Both male and female CA-users were three times more likely to be on alpha-blockers than non-users, p<0.001. CA-users were more likely to have undergone urinary tract-related surgery (Males: two times, p = 0.07 and females: nine times, p = 0.029). The study was limited by the fact that a causal relationship could not be established between CA use and LUTS. Conclusions Our results demonstrate an association between CA use and an increasing severity of LUTS. They also demonstrate that CA-users are more likely to have medical or surgical treatment for LUTS. However, these CA’s effects on LUTS vary, and the use of highly vascular selective agents does not appear to pose significant risk.

    Related items

    Showing items related by title, author, creator and subject.

    • Calcium antagonists-induced lower urinary tract symptoms
      Elhebir, Elsamaul Suliman A. (2011)
      Lower urinary tract symptoms (LUTS) are a group of obstructive and irritative urinary symptoms. These include storage, voiding, and post-micturition symptoms. LUTS are prevalent and bothersome in the rapidly growing ageing ...
    • Alcohol consumption, smoking and lifestyle characteristics for Japanese patients with chronic obstructive pulmonary disease
      Hirayama, Fumi (2008)
      This thesis investigated lifestyle characteristics including cigarette smoking, alcohol consumption, dietary supplements intake, physical activity, and urinary incontinence status for Japanese patients with chronic ...
    • Sexually dimorphic facial features vary according to level of autistic-like traits in the general population
      Gilani, S.; Tan, D.; Russell-Smith, S.; Maybery, M.; Mian, A.; Eastwood, Peter; Shafait, F.; Goonewardene, M.; Whitehouse, A. (2015)
      © 2015 Gilani et al.; licensee BioMed Central. Background: In a recent study, Bejerot et al. observed that several physical features (including faces) of individuals with an autism spectrum disorder (ASD) were more ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.