Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Plasma Amyloid-beta as a Biomarker in Alzheimer's Disease: The AIBL Study of Aging

    Access Status
    Fulltext not available
    Authors
    Lui, J.
    Laws, S.
    Li, Q.
    Villemagne, V.
    Ames, D.
    Brown, B.
    Bush, A.
    De Ruyck, K.
    Dromey, J.
    Ellis, K.
    Faux, N.
    Foster, Jonathan
    Fowlor, C.
    Gupta, V.
    Hudson, P.
    Laughton, K.
    Masters, C.
    Pertile, K.
    Rembach, A.
    Rimajova, M.
    Rodrigues, M.
    Rowe, C.
    Rumble, R.
    Szoeke, C.
    Taddei, K.
    Taddei, T.
    Trounson, B.
    Ward, V.
    Martins, R.
    Date
    2010
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Lui, J. and Laws, S. and Li, Q. and Villemagne, V. and Ames, D. and Brown, B. and Bush, A. et al. 2010. Plasma Amyloid-beta as a Biomarker in Alzheimer's Disease: The AIBL Study of Aging. Journal of Alzheimer's Disease. 20 (4): pp. 1233-1242.
    Source Title
    Journal of Alzheimer's Disease
    DOI
    10.3233/JAD-2010-090249
    ISSN
    13872877
    URI
    http://hdl.handle.net/20.500.11937/31314
    Collection
    • Curtin Research Publications
    Abstract

    Amyloid-β (Aβ) plays a central role in the pathogenesis of Alzheimer's disease (AD) and has been postulated as a potential biomarker for AD. However, there is a lack of consensus as to its suitability as an AD biomarker. The objective of this study was to determine the significance of plasma Aβ as an AD biomarker and its relationship with Aβ load and to determine the effect of different assay methods on the interpretation of Aβ levels. Plasma Aβ1-40, Aβ1-42, and N-terminal cleaved fragments were measured using both a commercial multiplex assay and a well-documented ELISA in 1032 individuals drawn from the well-characterized Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging. Further, Aβ levels were compared to Aβ load derived from positron-emission tomography (PET) with the Pittsburgh compound B (PiB). Lower Aβ1-42 and Aβ1-42/1-40 ratio were observed in patients with AD and inversely correlated with PiB-PET derived Aβ load. However, assay methodology significantly impacted the interpretation of data. The cross-sectional analysis of plasma Aβ isoforms suggests that they may not be sufficient per se to diagnose AD. The value of their measurement in prognosis and monitoring of AD interventions needs further study, in addition to future longitudinal comparisons together with other predictors, which will determine whether plasma Aβ has diagnostic value in a panel of biomarkers.

    Related items

    Showing items related by title, author, creator and subject.

    • Elevated plasma and urinary concentration of green tea catechins associated with improved plasma lipid profile in healthy Japanese women
      Takechi, Ryu; Alfonso, Helman; Hiramatsu, N.; Ishisaka, A.; Tanaka, A.; Tan, L.; Lee, Andy (2016)
      This study investigated green tea catechins in plasma and urine and chronic disease biomarkers. We hypothesized that plasma and urinary concentration of green tea catechins are associated with cardiovascular disease and ...
    • Plasma concentrations of coffee polyphenols and plasma biomarkers of diabetes risk in healthy Japanese women
      Lee, Andy; Tan, L.; Hiramatsu, N.; Ishisaka, A.; Alfonso, Helman; Tanaka, A.; Uemura, N.; Fujiwara, Y.; Takechi, Ryu (2016)
      Coffee consumption has been reported to reduce the risk of type 2 diabetes in experimental and epidemiological studies. This anti-diabetic effect of coffee may be attributed to its high content in polyphenols especially ...
    • Troponin T, N-terminal pro-B-type natriuretic peptide, and incidence of stroke: The atherosclerosis risk in communities study
      Folsom, A.; Nambi, V.; Bell, E.; Oluleye, O.; Gottesman, R.; Lutsey, P.; Huxley, Rachel; Ballantyne, C. (2013)
      Background and Purpose-Increased levels of plasma troponins and natriuretic peptides are associated with increased risk of cardiovascular disease, but only limited information exists on these biomarkers and stroke occurrence. ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.