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dc.contributor.authorReen, F.
dc.contributor.authorShanahan, R.
dc.contributor.authorCano, R.
dc.contributor.authorO'Gara, Fergal
dc.contributor.authorMcGlacken, G.
dc.date.accessioned2017-01-30T13:25:18Z
dc.date.available2017-01-30T13:25:18Z
dc.date.created2015-10-29T04:10:07Z
dc.date.issued2015
dc.identifier.citationReen, F. and Shanahan, R. and Cano, R. and O'Gara, F. and McGlacken, G. 2015. A structure activity-relationship study of the bacterial signal molecule HHQ reveals swarming motility inhibition in Bacillus atrophaeus. Organic and Biomolecular Chemistry. 13 (19): pp. 5537-5541.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/31432
dc.identifier.doi10.1039/c5ob00315f
dc.description.abstract

The sharp rise in antimicrobial resistance has been matched by a decline in the identification and clinical introduction of new classes of drugs to target microbial infections. Thus new approaches are being sought to counter the pending threat of a post-antibiotic era. In that context, the use of non-growth limiting small molecules, that target virulence behaviour in pathogens, has emerged as a solution with real clinical potential. We have previously shown that two signal molecules (HHQ and PQS) from the nosocomial pathogen Pseudomonas aeruginosa have modulatory activity towards other microorganisms. This current study involves the synthesis and evaluation of analogues of HHQ towards swarming and biofilm virulence behaviour in Bacillus atrophaeus, a soil bacterium and co-inhibitor with P. aeruginosa. Compounds with altered C6-C8 positions on the anthranilate-derived ring of HHQ, display a surprising degree of biological specificity, with certain candidates displaying complete motility inhibition. In contrast, anti-biofilm activity of the parent molecule was completely lost upon alteration at any position indicating a remarkable degree of specificity and delineation of phenotype.

dc.publisherRoyal Society of Chemistry
dc.titleA structure activity-relationship study of the bacterial signal molecule HHQ reveals swarming motility inhibition in Bacillus atrophaeus
dc.typeJournal Article
dcterms.source.volume13
dcterms.source.number19
dcterms.source.startPage5537
dcterms.source.endPage5541
dcterms.source.issn1477-0520
dcterms.source.titleOrganic and Biomolecular Chemistry
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusOpen access via publisher


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