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dc.contributor.authorSabarudin, Akmal
dc.contributor.authorSubramaniam, C.
dc.contributor.authorSun, Zhonghua
dc.identifier.citationSabarudin, A. and Subramaniam, C. and Sun, Z. 2014. Cerebral CT angiography and CT perfusion in acute stroke detection: a systematic review of diagnostic value. Quantitative Imaging in Medicine and Surgery. 4 (4): pp. 282-290.

The purpose of this study was to analyse the diagnostic value of cerebral CT angiography (CTA) and CT perfusion (CTP) examinations in the detection of acute stroke based on a systematic review of the current literature. The review was conducted based on searching of seven databases for articles published between 1993 and 2013. Diagnostic value in terms of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy was analysed from 21 articles which were found to meet selection criteria. The mean sensitivity, specificity, PPV, NPV and accuracy for CTA were significantly higher than those for CTP with 83.2% (95% CI: 57.9-100.0%), 95.0% (95% CI: 74.4-100%), 84.1% (95% CI: 50.0-100%), 97.1 (95% CI: 94.0-100%) and 94.0% (95% CI: 83.0-99.0) versus 69.9% (95% CI: 20.0-97.0%), 87.4 (95% CI: 61.0-100.0%), 76.4% (95% CI: 48.0-95.4%), 78.2% (95% CI: 55.8-93.9%) and 89.8% (95% CI: 75.7-97.1%), respectively. This analysis shows that CTA has high diagnostic value in detecting high degree of cerebral arterial stenosis (>70%) whereas CTP provides high specificity in the detection of ischemia and infarct tissue of brain.

dc.publisherAME Publishing Company
dc.subjectdiagnostic accuracy
dc.subjectCerebral CT angiography
dc.subjectCT perfusion (CTP)
dc.subjectacute stroke
dc.titleCerebral CT angiography and CT perfusion in acute stroke detection: a systematic review of diagnostic value
dc.typeJournal Article
dcterms.source.titleQuantitative Imaging in Medicine and Surgery
curtin.departmentDepartment of Imaging and Applied Physics
curtin.accessStatusOpen access

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