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    Characterization of imipenem resistance mechanisms in Pseudomonas aeruginosa isolates from Turkey

    Access Status
    Open access via publisher
    Authors
    Mac Aogáin, M.
    Kulah, C.
    Rijnsburger, M.
    Celebi, G.
    Savelkoul, P.
    O'Gara, Fergal
    Mooij, M.
    Date
    2012
    Type
    Journal Article
    
    Metadata
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    Citation
    Mac Aogáin, M. and Kulah, C. and Rijnsburger, M. and Celebi, G. and Savelkoul, P. and O'Gara, F. and Mooij, M. 2012. Characterization of imipenem resistance mechanisms in Pseudomonas aeruginosa isolates from Turkey. Clinical Microbiology and Infection. 18 (7): pp. E262-E265.
    Source Title
    Clinical Microbiology and Infection
    DOI
    10.1111/j.1469-0691.2012.03899.x
    ISSN
    1198743X
    URI
    http://hdl.handle.net/20.500.11937/31735
    Collection
    • Curtin Research Publications
    Abstract

    The emergence of carbapenem resistance in Pseudomonas aeruginosa threatens the efficacy of this important anti-pseudomonal antibiotic class. Between 2003 and 2006, an increase in the number of carbapenem-resistant P. aeruginosa isolates at the Zonguldak Karaelmas University Hospital was observed (Zongul-dak, Turkey). To assess the imipenem resistance mechanisms emerging in these P. aeruginosa isolates, they were characterized by amplified fragment length polymorphism typing, which revealed diversity among imipenem-resistant isolates as well as two clonally related outbreak groups. The molecular mechanism of carbapenem resistance was characterized in a representative isolate from each clonal group. Mutational disruption of oprD was the most frequently encountered resistance mechanism (23/27 isolates).

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