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dc.contributor.authorWatson, Charles
dc.contributor.authorLind, C.
dc.contributor.authorThomas, M.
dc.date.accessioned2017-01-30T13:28:29Z
dc.date.available2017-01-30T13:28:29Z
dc.date.created2015-03-15T20:00:27Z
dc.date.issued2014
dc.identifier.citationWatson, C. and Lind, C. and Thomas, M. 2014. The anatomy of the caudal zona incerta in rodents and primates. Journal of Anatomy. 224 (2): pp. 95-107.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/31973
dc.identifier.doi10.1111/joa.12132
dc.description.abstract

The caudal zona incerta is the target of a recent modification of established procedures for deep brain stimulation (DBS) for Parkinson's disease and tremor. The caudal zona incerta contains a number of neuronal populations that are distinct in terms of their cytoarchitecture, connections, and pattern of immunomarkers and is located at a position where a number of major tracts converge before turning toward their final destination in the forebrain. However, it is not clear which of the anatomical features of the region are related to its value as a target for DBS. This paper has tried to identify features that distinguish the caudal zona incerta of rodents (mouse and rat) and primates (marmoset, rhesus monkey, and human) from the remainder of the zona incerta. We studied cytoarchitecture, anatomical relationships, the pattern of immunomarkers, and gene expression in both of these areas. We found that the caudal zona incerta has a number of histological and gene expression characteristics that distinguish it from the other subdivisions of the zona incerta. Of particular note are the sparse population of GABA neurons and the small but distinctive population of calbindin neurons. We hope that a clearer appreciation of the anatomy of the region will in the end assist the interpretation of cases in which DBS is used in human patients.

dc.publisherWiley Blackwell Publishing Ltd
dc.subjectsubthalamic nucleus
dc.subjectParkinson's disease
dc.subjectcaudal zona incerta
dc.subjectdeep brain stimulation
dc.subjectzona incerta
dc.titleThe anatomy of the caudal zona incerta in rodents and primates
dc.typeJournal Article
dcterms.source.volume224
dcterms.source.number2
dcterms.source.startPage95
dcterms.source.endPage107
dcterms.source.issn0021-8782
dcterms.source.titleJournal of Anatomy
curtin.accessStatusOpen access via publisher
curtin.facultyFaculty of Health Sciences


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