Prediction of thrombus formation using vortical structures presentation in Stanford type B aortic dissection: A preliminary study using CFD approach
MetadataShow full item record
False lumen patency has been recognized as the key determinant of aneurismal dilatation and rupture, whereas complete thrombosis has been proven clinically to improve disease outcomes. However, to date, there is no definitive method that could predict false lumen thrombosis in Stanford type B aortic dissection patient. The present study aims to use the evolution of vortical structures throughout a cardiac cycle and its interaction with the wall shear stress (WSS) to illustrate the potential mechanism behind the formation of thrombus and predict its highly possible location in an aortic dissection patient. A three-dimensional (3D) patient-specific Stanford type B aortic dissection domain was generated from computed tomography (CT) angiographic images. The effects of false lumen size on vortical structures and the subsequent risk of thrombus formation were investigated. The Carreau–Yasuda model, representing non-Newtonian fluid property was used to study the difference between Newtonian and non-Newtonian fluid settings on vortical structures. Based on our analysis, we predicted that the formation and thickening of thrombus is very much likely to occur at the posterior false lumen wall, distal to the entry tear region, in the patient. Higher λ2 intensity, associated with a higher maximum WSS and a lower minimum WSS, was achieved with an increase in the false lumen size, and we believed that this increases the risk of thrombus formation and thus aneurismal dilatation. On the other hand, percentage of flow entering the false lumen increased with an increase in the false lumen size, leading to a downward shift of the areas of thrombus formation along the false lumen wall.
Showing items related by title, author, creator and subject.
Liu, D.; Liu J; Wen, Z.; Li, Y.; Sun, Zhonghua; Xu, Q.; Fan, Z. (2017)Objective: To investigate the clinical value of renal perfusion imaging in patients with aortic dissection (AD) using 320-row computed tomography (CT), and to determine the relationship between renal CT perfusion imaging ...
Ho, Daniel; Squelch, Andrew; Sun, Zhonghua (2017)Introduction: The aim of this study was to assess if the complex anatomy of aortic aneurysm and aortic dissection can be accurately reproduced from a contrast-enhanced computed tomography (CT) scan into a three-dimensional ...
Sun, Zhonghua; Cao, Y. (2010)AIM: To present our experience of using 3D virtual intravascular endoscopy (VIE) to characterize and evaluate the intraluminal appearances of aortic dissection. METHODS: Ten patients with known aortic dissection underwent ...