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dc.contributor.authorMulrennan, S.
dc.contributor.authorBaltic, S.
dc.contributor.authorAggarwal, S.
dc.contributor.authorWood, J.
dc.contributor.authorMiranda, Alina
dc.contributor.authorFrost, F.
dc.contributor.authorKaye, J.
dc.contributor.authorThompson, P.
dc.date.accessioned2017-01-30T13:31:47Z
dc.date.available2017-01-30T13:31:47Z
dc.date.created2016-03-03T19:30:22Z
dc.date.issued2015
dc.identifier.citationMulrennan, S. and Baltic, S. and Aggarwal, S. and Wood, J. and Miranda, A. and Frost, F. and Kaye, J. et al. 2015. The Role of Receptor for Advanced Glycation End Products in Airway Inflammation in CF and CF related Diabetes. Scientific Reports. 5: 8931.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/32583
dc.identifier.doi10.1038/srep08931
dc.description.abstract

Cystic Fibrosis (CF) is often accompanied by diabetes leading to worsening lung function, the reason for which is unclear. The receptor for advanced-glycation-end-products (RAGE) regulates immune responses and inflammation and has been linked to diabetes and possibly CF. We performed a pilot study to determine if CF and CF-related diabetes (CFRD) are associated with enhanced RAGE expression. Full length (fl)RAGE, soluble (s)RAGE, endogenous soluble (es)RAGE, S100A12 (enRAGE) and advanced-glycation-end-products (AGE) expression was assessed in serum, white blood cells and sputum of patients with CF; diabetes; CFRD and healthy subjects. Sputum enRAGE/sRAGE ratios were high in CF but particularly in CFRD which negatively correlated with % predicted FEV1. Serum AGE and AGE/sRAGE ratios were high in diabetics but not in CF. A complex, multifaceted approach was used to assess the role of RAGE and its ligands which is fundamental to determining their impact on airway inflammation. There is a clear association between RAGE activity in the airways of CF and CFRD patients that is not evident in the vascular compartment and correlates with lung function, in contrast to diabetes. This strongly suggests a role for RAGE in contributing to the inflammatory overdrive seen in CF and to a greater extent in CFRD.

dc.publisherNature Publishing Group
dc.titleThe Role of Receptor for Advanced Glycation End Products in Airway Inflammation in CF and CF related Diabetes
dc.typeJournal Article
dcterms.source.volume5
dcterms.source.startPage1
dcterms.source.endPage9
dcterms.source.issn2045-2322
dcterms.source.titleScientific Reports
curtin.note

This open access article is distributed under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusOpen access


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