Molecular delivery of plasmids for genetic vaccination
MetadataShow full item record
Plasmid vaccination is a smart gene delivery application mostly achieved through the utilisation of viral or copolymeric systems as surrogated carriers in micro or nano formulations. A common polymeric protocol for plasmid vaccine formulation, which as somewhat been successful, is via the complexation of the DNA molecules with a cationic polymer, and encapsulating in a vehicular carrier polymer. Even though plasmid vaccination research has not witnessed the much anticipated success, due a number of cellular and physicochemical reasons, application of copolymeric carriers with tight functionalities is a promising strategy to optimally deliver the DNA molecules; in view of the available chemistries and physical properties that could be tuned to enable enhanced targeted delivery, uptake and specific transfection. This also enables the targeting of specific epitopes and antigen presenting cells for the treatment of many pathogenic infections and cancer. This paper provides a brief critical review of the current state of plasmid vaccines formulation and molecular delivery with analysis of performance data obtained from clinical trials.
Showing items related by title, author, creator and subject.
Ongkudon, C.; Ho, J.; Danquah, Michael (2011)The exponentially growing human population and the emergence of new diseases are clear indications that the world can no longer depend solely on conventional vaccine technologies and production schemes. The race to find ...
Synthesis of biodegradable polymer-mesoporous silica composite microspheres for DNA prime-protein boost vaccinationHo, J.; Huang, Y.; Danquah, Michael; Wang, H.; Forde, G. (2010)DNA vaccines or proteins are capable of inducing specific immunity; however, the translation to the clinic has generally been problematic, primarily due to the reduced magnitude of immune response and poor pharmacokinetics. ...
Mass Vaccination with a New, Less Expensive Oral Cholera Vaccine Using Public Health Infrastructure in India: The Odisha ModelKar, S.; Sah, B.; Patnaik, B.; Kim, Y.; Kerketta, A.; Shin, S.; Rath, S.; Ali, Mohammed; Mogasale, V.; Khuntia, H.; Bhattachan, A.; You, Y.; Puri, M.; Lopez, A.; Maskery, B.; Nair, G.; Clemens, J.; Wierzba, T. (2014)Introduction: The substantial morbidity and mortality associated with recent cholera outbreaks in Haiti and Zimbabwe, as well as with cholera endemicity in countries throughout Asia and Africa, make a compelling case for ...