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    Regulatory principles in metabolism -Then and now

    Access Status
    Fulltext not available
    Authors
    Curi, R.
    Newsholme, P.
    Marzuca-Nassr, G.
    Takahashi, H.
    Hirabara, S.
    Cruzat, Vinicius
    Krause, M.
    De Bittencourt, P.
    Date
    2016
    Type
    Journal Article
    
    Metadata
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    Citation
    Curi, R. and Newsholme, P. and Marzuca-Nassr, G. and Takahashi, H. and Hirabara, S. and Cruzat, V. and Krause, M. et al. 2016. Regulatory principles in metabolism -Then and now. Biochemical Journal. 473 (13): pp. 1845-1857.
    Source Title
    Biochemical Journal
    DOI
    10.1042/BCJ20160103
    ISSN
    0264-6021
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/3286
    Collection
    • Curtin Research Publications
    Abstract

    The importance of metabolic pathways for life and the nature of participating reactions have challenged physiologists and biochemists for over a hundred years. Eric Arthur Newsholme contributed many original hypotheses and concepts to the field of metabolic regulation, demonstrating that metabolic pathways have a fundamental thermodynamic structure and that near identical regulatory mechanisms exist in multiple species across the animal kingdom. His work at Oxford University from the 1970s to 1990s was groundbreaking and led to better understanding of development and demise across the lifespan as well as the basis of metabolic disruption responsible for the development of obesity, diabetes and many other conditions. In the present review we describe some of the original work of Eric Newsholme, its relevance to metabolic homoeostasis and disease and application to present state-of-The-Art studies, which generate substantial amounts of data that are extremely difficult to interpret without a fundamental understanding of regulatory principles. Eric's work is a classical example of how one can unravel very complex problems by considering regulation from a cell, tissue and whole body perspective, thus bringing together metabolic biochemistry, physiology and pathophysiology, opening new avenues that now drive discovery decades thereafter.

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