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    Observational research on alcohol use and chronic disease outcome: New approaches to counter biases

    193639_98318_New_Approaches_to_Counter_Biases_2013_.pdf (1.413Mb)
    Access Status
    Open access
    Authors
    Liang, Wenbin
    Chikritzhs, Tanya
    Date
    2013
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Liang, Wenbin and Chikritzhs, Tanya. 2013. Observational research on alcohol use and chronic disease outcome: New approaches to counter biases. The Scientific World Journal. 2013 (860915): pp 1-14.
    Source Title
    the scientific world journal
    DOI
    10.1155/2013/860915
    ISSN
    1537744X
    Remarks

    This article is published under the Open Access publishing model and distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/. Please refer to the licence to obtain terms for any further reuse or distribution of this work.

    URI
    http://hdl.handle.net/20.500.11937/33103
    Collection
    • Curtin Research Publications
    Abstract

    Background. The frequently reported protective effects of moderate alcohol consumption in observational studies may be due to unadjusted bias. Aim. To examine two new approaches that account for unknown confounding factors and allow the application of intention-to-treat analysis. Method. This study used data from the 2008, 2009, and 2010 National Health Interview Surveys conducted in the United States. Unknown confounding effects were estimated through the association between parental alcohol use and health outcomes for children, because the presence of hypothetical physiological effects of alcohol can be ruled out for this association. In order to apply intention-to-treat analysis, previous alcohol use of former drinkers was obtained by using multiple imputations. Estimates with new adjustment approaches were compared with the traditional approach. Results. The traditional analytical approach; appears to be consistent with findings from previous observational studies; when two further adjustment approaches were used, the “protective” effects of moderate drinking almost disappeared. Conclusion. Use of a proxy outcome to estimate and control residual confounding effects of alcohol use and application of the intention-to-treat principle could provide a more realistic estimation of the true effects of alcohol use on health outcomes in observational epidemiological studies.

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