Secreted Frizzled-Related Protein 4 expression is positively associated with responsiveness to Cisplatin of ovarian cancer cell lines in vitro and with lower tumour grade in mucinous ovarian cancers
dc.contributor.author | Saran, U. | |
dc.contributor.author | Arfuso, F. | |
dc.contributor.author | Zeps, N. | |
dc.contributor.author | Dharmarajan, Arunasalam | |
dc.date.accessioned | 2017-01-30T13:36:03Z | |
dc.date.available | 2017-01-30T13:36:03Z | |
dc.date.created | 2012-10-31T20:00:26Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Saran, Uttara and Arfuso, Frank and Zeps, Nikolajs and Dharmarajan, Arunasalam. 2012. Secreted Frizzled-Related Protein 4 expression is positively associated with responsiveness to Cisplatin of ovarian cancer cell lines in vitro and with lower tumour grade in mucinous ovarian cancers. BMC Cell Biology. 13: pp. 25. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/33260 | |
dc.identifier.doi | 10.1186/1471-2121-13-25 | |
dc.description.abstract |
Ovarian cancer is one of the most lethal malignancies in women, as it is frequently detected at an advanced stage, and cancers often become refractory to chemotherapy. Evidence suggests that dysregulation of pro-apoptotic genes plays a key role in the onset of chemoresistance. The secreted Frizzled-Related Protein (sFRP) family is pro-apoptotic and also a negative modulator of the Wnt signalling cascade. Studies have demonstrated that the re-expression of sFRPs, in particular sFRP4, is associated with a better prognosis, and that experimentally induced expression results in cell death. | |
dc.publisher | BioMed Central Ltd. | |
dc.subject | Tumour biopsy | |
dc.subject | Ovarian cancer | |
dc.subject | Secreted frizzled-related protein 4 | |
dc.subject | Cisplatin | |
dc.subject | Chemosensitivity | |
dc.subject | Chemoresistance | |
dc.title | Secreted Frizzled-Related Protein 4 expression is positively associated with responsiveness to Cisplatin of ovarian cancer cell lines in vitro and with lower tumour grade in mucinous ovarian cancers | |
dc.type | Journal Article | |
dcterms.source.volume | 13 | |
dcterms.source.number | 25 | |
dcterms.source.issn | 1471-2121 | |
dcterms.source.title | BMC Cell Biology | |
curtin.note |
First published as cited above © BMJ Publishing Group Ltd | |
curtin.note |
This article is published under the Open Access publishing model and distributed under the terms of the Creative Commons Attribution License | |
curtin.department | ||
curtin.accessStatus | Open access |