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    Obesity and overweight in relation to liver disease mortality in men: 38 Year follow-up of the original Whitehall study

    Access Status
    Open access via publisher
    Authors
    Batty, G.
    Shipley, M.
    Kivimaki, M.
    Barzi, F.
    Smith, G.
    Mitchell, R.
    Marmot, M.
    Huxley, Rachel
    Date
    2008
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Batty, G. and Shipley, M. and Kivimaki, M. and Barzi, F. and Smith, G. and Mitchell, R. and Marmot, M. et al. 2008. Obesity and overweight in relation to liver disease mortality in men: 38 Year follow-up of the original Whitehall study. International Journal of Obesity. 32 (11): pp. 1741-1744.
    Source Title
    International Journal of Obesity
    DOI
    10.1038/ijo.2008.162
    ISSN
    0307-0565
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/33282
    Collection
    • Curtin Research Publications
    Abstract

    Obesity has been implicated in the aetiology of liver disease. However, to date, evidence is largely drawn from cross-sectional studies, where interpretation is hampered by reverse causality, and from studies on clinical populations that have limited generalisability. In this prospective cohort study, data on body mass index (BMI) and covariates were collected at baseline on 18 863 male government employees (aged 40-69 years). Respondents were then followed up for a maximum of 38 years of age. Mortality surveillance gave rise to 13 129 deaths, 122 of which were due to liver disease (57 cancers; 65 non-cancers). In age-adjusted analyses, BMI was positively related to total liver disease mortality (hazards ratio per 1 s.d. increase in BMI; 95% confidence interval (CI): 1.36; 1.14, 1.62) in a graded fashion across the weight categories (P-value for trend: 0.01). The magnitude of this association was somewhat stronger for non-cancer liver disease deaths (1.47; 1.16, 1.86) than for cancer liver disease deaths (1.25; 0.96, 1.62). Excluding deaths in the first 10 years of follow-up somewhat strengthened the BMI - non-cancer liver disease association. Adjustment for socioeconomic position, other candidate confounders and mediating factors led to the modest attenuation of these associations. Further investigation in prospective cohort studies with more detailed data on liver disease, for instance using biochemical tests of liver function or hepatic ultrasonography, is warranted. © 2008 Macmillan Publishers Limited All rights reserved.

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