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dc.contributor.authorMargassery, L.
dc.contributor.authorKennedy, J.
dc.contributor.authorO'Gara, Fergal
dc.contributor.authorDobson, A.
dc.contributor.authorMorrissey, J.
dc.date.accessioned2017-01-30T13:36:17Z
dc.date.available2017-01-30T13:36:17Z
dc.date.created2015-03-03T03:50:50Z
dc.date.issued2012
dc.identifier.citationMargassery, L. and Kennedy, J. and O'Gara, F. and Dobson, A. and Morrissey, J. 2012. A high-throughput screen to identify novel calcineurin inhibitors. Journal of Microbiological Methods. 88 (1): pp. 63-66.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/33306
dc.identifier.doi10.1016/j.mimet.2011.10.012
dc.description.abstract

Calcineurin is a eukaryotic protein phosphatase important for many signalling and developmental processes in cells. Inhibitors of this enzyme are used clinically and there is interest in identifying novel inhibitors for therapeutic applications. This report describes a high-throughput assay that can be used to screen natural or chemical libraries of compounds to identify new calcineurin inhibitors. The microtitre plate assay is based on a yeast reporter strain and was validated with known inhibitors and tested in a pilot screen of bacterial extracts.

dc.publisherElsevier Inc
dc.titleA high-throughput screen to identify novel calcineurin inhibitors
dc.typeJournal Article
dcterms.source.volume88
dcterms.source.number1
dcterms.source.startPage63
dcterms.source.endPage66
dcterms.source.issn0167-7012
dcterms.source.titleJournal of Microbiological Methods
curtin.accessStatusFulltext not available


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