Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Development of polylactide and polyethylene vinyl acetate blends for the manufacture of vaginal rings

    Access Status
    Fulltext not available
    Authors
    McConville, Christopher
    Major, Ian
    Friend, David
    Clark, Meredith
    Woolfson, A
    Malcolm, R
    Date
    2012
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    McConville, Christopher and Major, Ian and Friend, David and Clark, Meredith and Woolfson, A. David and Malcolm, R. Karl. 2012. Development of polylactide and polyethylene vinyl acetate blends for the manufacture of vaginal rings. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 100B (4): pp. 891-895.
    Source Title
    Journal of Biomedical Materials Research. Part B: Applied Biomaterials
    DOI
    10.1002/jbm.b.31919
    ISSN
    1552-4973
    URI
    http://hdl.handle.net/20.500.11937/3337
    Collection
    • Curtin Research Publications
    Abstract

    Vaginal rings are currently being investigated for delivery of HIV microbicides. However, vaginal rings are currently manufactured form hydrophobic polymers such as silicone elastomer and polyethylene vinyl acetate (PEVA), which do not permit release of hydrophilic microbicides such as the nucleotide reverse transcriptase inhibitor tenofovir. Biodegradable polymers such as polylactide (PLA) may help increase release rates by controlling polymer degradation rather than diffusion of the drug through the polymer. However, biodegradable polymers have limited flexibility making them unsuitable for use in the manufacture of vaginal rings. This study demonstrates that by blending PLA and PEVA together it is possible to achieve a blend that has flexibility similar to native PEVA but also allows for the release of tenofovir.

    Related items

    Showing items related by title, author, creator and subject.

    • The degradation of plastics & rubbers used in corrosion protection systems
      Jefferson, Alan; Kinsella, Brian (2006)
      Thermoplastics, thermoset resins, rubbers and chemicals which are used for corrosion protection may themselves be the subject of degradation through mechanisms that are not related to solar radiation. Coatings, liners, ...
    • Quasi-static bending and low velocity impact performance of monolithic and laminated glass windows employing chemically strengthened glass
      Mohagheghian, I.; Wang, Y.; Jiang, L.; Zhang, Xihong; Guo, X.; Yan, Y.; Kinloch, A.; Dear, J. (2017)
      © 2017 Elsevier Masson SAS In this paper, firstly the quasi-static bending performance of chemically strengthened alumina silicate glass plates is investigated for different glass thicknesses: 2.2, 4.0 and 6.0 mm. The ...
    • ROMP Synthesis of Novel Thermo-, pH, and Salt Responsive (Co)Polymers Containing the Morpholino Functional Group
      van Hensbergen, J.; Ganda, S.; Roth, P.; Burford, R.; Lowe, Andrew (2015)
      We report the ring-opening metathesis polymerization (ROMP) synthesis of novel (co)polymers containing the multiresponsive morpholino functional group [(3aR,7aS)−2-(2-morpholinoethyl)−3a,4,7,7a-tetrahydro-1H−4,7-epoxyis ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.