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    Spontaneous regression of CIN2 in women aged 18-24 years: a retrospective study of a state-wide population in Western Australia

    235678_235678a.pdf (350.7Kb)
    Access Status
    Open access
    Authors
    Munro, Aime
    Powell, Rees
    Cohen, P.
    Bowen, S.
    Spilsbury, Katrina
    O'Leary, Peter
    Semmens, James
    Codde, J.
    Williams, Vincent
    Steel, N.
    Leung, Yee-Hong
    Date
    2015
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Munro, A. and Powell, R. and Cohen, P. and Bowen, S. and Spilsbury, K. and O'Leary, P. and Semmens, J. et al. 2015. Spontaneous regression of CIN2 in women aged 18-24 years: a retrospective study of a state-wide population in Western Australia. Acta Obstetricia et Gynecologica Scandinavica. 95: pp. 291-298.
    Source Title
    Acta Obstet Gynecol Scand
    DOI
    10.1111/aogs.12835
    School
    Centre for Population Health Research
    Remarks

    This is the peer reviewed version of the following article: Munro, A. and Powell, R. and Cohen, P. and Bowen, S. and Spilsbury, K. and O'Leary, P. and Semmens, J. et al. 2015. Spontaneous regression of CIN2 in women aged 18-24 years: a retrospective study of a state-wide population in Western Australia. Acta Obstetricia et Gynecologica Scandinavica. 95: pp. 291-298, which has been published in final form at http://doi.org/10.1111/aogs.12835. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving at http://olabout.wiley.com/WileyCDA/Section/id-820227.html#terms

    URI
    http://hdl.handle.net/20.500.11937/33414
    Collection
    • Curtin Research Publications
    Abstract

    Introduction: CIN2 has a high rate of spontaneous regression in young women and may be managed conservatively in appropriately selected patients. This study aimed to investigate health outcomes in women aged 18–24 years with biopsy-confirmed CIN2. Material and methods: A retrospective cohort study of Western Australian women aged 18–24 years diagnosed with CIN2 on cervical biopsy from 1 January 2001 to 31 December 2010. Women who had not received treatment at ≥4 months following CIN2 diagnosis were classified as managed ‘conservatively’. Subsequent cervical cytology and/or biopsy test results were used to report lesion regression (absence of dysplasia or an epithelial lesion of lower grade than CIN2) and disease persistence (CIN2, CIN3 or ACIS). Results: Follow-up data were available for 2417 women of whom 924 (38.2%) were ‘conservatively’ managed. In all, 152 (16.4%) conservatively managed women had a lesion more severe than CIN2 detected within 24 months of initial diagnosis, of which 144 were CIN3 and eight were ACIS. There was no statistically significant association between rates of regression and patient age, Socio-economic Indexes for Areas or Accessibility/Remoteness Index of Australia indices. The 2-year regression rate for CIN2 was estimated to be 59.5% (95%CI 0.5–0.6) in this cohort of women. Conclusion: In conservatively managed young women with CIN2 there was a high rate of spontaneous disease regression. Thus, excisional or ablative treatments may be avoided in selected patients who receive appropriate counseling and who are able to comply with more intensive and prolonged follow-up requirements.

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