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    Epigenome-wide search for association of serum 25-hydroxyvitamin D concentration with leukocyte DNA methylation in a large cohort of older men

    Access Status
    Fulltext not available
    Authors
    Florath, Ines
    Schöttker, B.
    Butterbach, K.
    Bewerunge-Hudler, M.
    Brenner, H.
    Date
    2016
    Type
    Journal Article
    
    Metadata
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    Citation
    Florath, I. and Schöttker, B. and Butterbach, K. and Bewerunge-Hudler, M. and Brenner, H. 2016. Epigenome-wide search for association of serum 25-hydroxyvitamin D concentration with leukocyte DNA methylation in a large cohort of older men. Epigenomics. 8 (4): pp. 487-499.
    Source Title
    Epigenomics
    DOI
    10.2217/epi.16.4
    School
    Epidemiology and Biostatistics
    URI
    http://hdl.handle.net/20.500.11937/33447
    Collection
    • Curtin Research Publications
    Abstract

    Aim: We aimed for an epigenome-wide identification of vitamin D-associated CpG sites in leukocyte DNA. Materials & methods: Infinium HumanMethylation450BeadChip measurements in 402 Caucasian older men were evaluated for significant association with 25-hydroxy-vitamin (25(OH)D) using Spearman's correlation and median regression to adjust for confounding variables. A cross-validation approach as well as a bootstrapping procedure were implemented to determine the replicability of significant associations. Multiple testing was corrected for by Benjamini–Hochberg or Bonferroni. Results: Although in the screening subcohorts significant associations of DNAm with 25(OH)D were observed in the validation cohorts these associations were not replicated after adjustment for potential confounders. At none of the 361,945 CpGs a significant association of DNAm with 25(OH)D was found in all 100 random bootstrap samples, but in comparison at 462 CpGs for the well-established association with age. Conclusion: Leukocyte DNAm was not associated with 25(OH)D levels after validation and consideration of confounders.

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