Mechanisms of PEDF-mediated protection against reactive oxygen species damage in diabetic retinopathy and neuropathy
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Open access via publisher
Authors
Elahy, M.
Baindur-Hudson, S.
Newsholme, Philip
Dass, Crispin
Date
2014Type
Journal Article
Metadata
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Elahy, M. and Baindur-Hudson, S. and Newsholme, P. and Dass, C. 2014. Mechanisms of PEDF-mediated protection against reactive oxygen species damage in diabetic retinopathy and neuropathy. Journal of Endocrinology. 222 (3): pp. R129-R139.
Source Title
Journal of Endocrinology
ISSN
School
School of Biomedical Sciences
Collection
Abstract
Pigment epithelium-derived factor (PEDF) is a pluripotent glycoprotein belonging to the serpin family. PEDF can stimulate several physiological processes such as angiogenesis, cell proliferation and survival. Oxidative stress plays an important role in the occurrence of diabetic retinopathy (DR) which is the major cause of blindness in young diabetic adults. PEDF plays a protective role in DR and there is accumulating evidence of the neuroprotective effect of PEDF. In this paper, we review the role of PEDF and the mechanisms involved in its antioxidative, anti-inflammatory and neuroprotective properties.
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