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    Programmable mechanical stimulation influences tendon homeostasis in a bioreactor system

    Access Status
    Fulltext not available
    Authors
    Wang, Tao
    Lin, Zhen
    Day, Robert
    Gardiner, Bruce
    Landao-Bassonga, Euphemie
    Rubenson, Jonas
    Kirk, Brett
    Smith, David
    Lloyd, David
    Hardisty, Gerard
    Wang, Allan
    Zheng, Qiujian
    Zheng, Ming Hao
    Date
    2013
    Type
    Journal Article
    
    Metadata
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    Citation
    Wang, T and Lin, Z and Day, R and Gardiner, B and Landao-Bassonga, E and Rubenson, J and Kirk, Thomas B. et al. 2013. Programmable mechanical stimulation influences tendon homeostasis in a bioreactor system. Biotechnology and Bioengineering. 110 (5): pp. 1495-1507.
    Source Title
    Biotechnology and Bioengineering
    DOI
    10.1002/bit.24809
    ISSN
    00063592
    URI
    http://hdl.handle.net/20.500.11937/33841
    Collection
    • Curtin Research Publications
    Abstract

    Identification of functional programmable mechanical stimulation (PMS) on tendon not only provides the insight of the tendon homeostasis under physical/pathological condition, but also guides a better engineering strategy for tendon regeneration. The aims of the study are to design a bioreactor system with PMS to mimic the in vivo loading conditions, and to define the impact of different cyclic tensile strain on tendon. Rabbit Achilles tendons were loaded in the bioreactor with/without cyclic tensile loading (0.25 Hz for 8 h/day, 0–9% for 6 days). Tendons without loading lost its structure integrity as evidenced by disorientated collagen fiber, increased type III collagen expression, and increased cell apoptosis. Tendons with 3% of cyclic tensile loading had moderate matrix deterioration and elevated expression levels of MMP-1, 3, and 12, whilst exceeded loading regime of 9% caused massive rupture of collagen bundle. However, 6% of cyclic tensile strain was able to maintain the structural integrity and cellular function. Our data indicated that an optimal PMS is required to maintain the tendon homeostasis and there is only a narrow range of tensile strain that can induce the anabolic action. The clinical impact of this study is that optimized eccentric training program is needed to achieve maximum beneficial effects on chronic tendinopathy management.

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