Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Diagnostic Accuracies of Glycated Hemoglobin, Fructosamine, and Homeostasis Model Assessment of Insulin Resistance in Predicting Impaired Fasting Glucose, Impaired Glucose Tolerance, or New Onset Diabetes After Transplantation

    Access Status
    Open access via publisher
    Authors
    Rosettenstein, K.
    Viecelli, A.
    Yong, K.
    Nguyen, H.
    Chakera, Aron
    Chan, D.
    Dogra, G.
    Lim, E.
    Wong, G.
    Lim, W.
    Date
    2015
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Rosettenstein, K. and Viecelli, A. and Yong, K. and Nguyen, H. and Chakera, A. and Chan, D. and Dogra, G. et al. 2015. Diagnostic Accuracies of Glycated Hemoglobin, Fructosamine, and Homeostasis Model Assessment of Insulin Resistance in Predicting Impaired Fasting Glucose, Impaired Glucose Tolerance, or New Onset Diabetes After Transplantation. Transplantation.
    Source Title
    Transplantation
    DOI
    10.1097/TP.0000000000000949
    ISSN
    0041-1337
    School
    Curtin Medical School
    URI
    http://hdl.handle.net/20.500.11937/33844
    Collection
    • Curtin Research Publications
    Abstract

    © 2015 Wolters Kluwer Health, Inc. All rights reserved. BACKGROUND: New onset diabetes after transplantation (NODAT) is associated with a 3-fold greater risk of cardiovascular disease events, with early identification and treatment potentially attenuating this risk. The optimal screening test to identify those with NODAT remains unclear, and the aim of this study was to examine the diagnostic accuracies of 4 screening tests in identifying impaired fasting glucose, impaired glucose tolerance (IGT), and NODAT. METHODS: This is a single-center prospective cohort study of 83 nondiabetic kidney transplant recipients between 2008 and 2011. Oral glucose tolerance test was considered the gold standard in identifying IFG/IGT or NODAT. Diagnostic accuracies of random blood glucose, glycated hemoglobin (HBA1c), fructosamine, and Homeostasis Model Assessment-Insulin Resistance in predicting IFG/IGT or NODAT were assessed using the area under the receiver operating characteristic curve. RESULTS: Forty (48%) recipients had IFG/IGT or NODAT. Compared with HBA1c with adjusted area under the curve (AUC) of 0.88 (95% confidence interval [95% CI], 0.77-0.93), fructosamine was the most accurate test with adjusted AUC of 0.92 (95% CI, 0.83-0.96). The adjusted AUCs of random blood glucose and Homeostasis Model Assessment-Insulin Resistance in identifying IFG/IGT were between 0.81 and 0.85. Restricting to identifying IGT/NODAT using 2-hour oral glucose tolerance test (n = 66), fructosamine was the most accurate diagnostic test with adjusted AUC of 0.93 (95% CI, 0.84-0.99), but not statistically different to HBA1c with adjusted AUC of 0.88 (95% CI, 0.76-0.96). CONCLUSIONS: Although HBA1c is an acceptable and widely used screening test in detecting IFG/IGT or NODAT, fructosamine may be a more accurate diagnostic test but this needs to be further examined in larger cohorts.

    Related items

    Showing items related by title, author, creator and subject.

    • Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes
      Solimena, Michele; Schulte, A.; Marselli, L.; Ehehalt, F.; Richter, D.; Kleeberg, M.; Mziaut, H.; Knoch, K.; Parnis, J.; Bugliani, M.; Siddiq, A.; Jörns, A.; Burdet, F.; Liechti, R.; Suleiman, M.; Margerie, D.; Syed, F.; Distler, M.; Grützmann, R.; Petretto, E.; Moreno-Moral, A.; Wegbrod, C.; Sönmez, A.; Pfriem, K.; Friedrich, A.; Meinel, J.; Wollheim, C.; Baretton, G.; Scharfmann, R.; Nogoceke, E.; Bonifacio, E.; Sturm, D.; Meyer-Puttlitz, B.; Boggi, U.; Saeger, H.; Filipponi, F.; Lesche, M.; Meda, P.; Dahl, A.; Wigger, L.; Xenarios, I.; Falchi, M.; Thorens, B.; Weitz, J.; Bokvist, K.; Lenzen, S.; Rutter, G.; Froguel, P.; von Bülow, M.; Ibberson, M.; Marchetti, P. (2018)
      © 2017, The Author(s). Aims/hypothesis: Pancreatic islet beta cell failure causes type 2 diabetes in humans. To identify transcriptomic changes in type 2 diabetic islets, the Innovative Medicines Initiative for Diabetes: ...
    • The influence of ethnicity and glucose tolerance status on subjective hunger sensations and prospective food intake in overweight and obese Asian and European Australians
      Muhardi, L.; Zhao, Yun; Solah, Vicky; Fyfe, Sue; Soares, Mario (2017)
      © 2017 Diabetes India Aims To examine the influence of ethnicity and glucose tolerance status on subjective sensations and food intake in overweight/obese Asian and European Australians. Methods 18 Asians and 26 Europids ...
    • What price a diagnosis? Targeting patients for diabetic screening
      Jiwa, Moyez; Freeman, J.; Clayton, C.; Bundy, J.; Wilson, P. (2004)
      The natural history of impaired carbohydrate metabolism has not been established although the importance of identifying patients with abnormally high blood glucose levels has been highlighted internationally. This survey ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.