The oxysterol-binding protein superfamily: New concepts and old proteins
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Open access via publisher
Authors
Villasmil, M.
Bankaitis, V.
Mousley, Carl
Date
2012Type
Journal Article
Metadata
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Villasmil, M. and Bankaitis, V. and Mousley, C. 2012. The oxysterol-binding protein superfamily: New concepts and old proteins. Biochemical Society Transactions. 40 (2): pp. 469-473.
Source Title
Biochemical Society Transactions
ISSN
School
School of Biomedical Sciences
Collection
Abstract
The Kes1 OSBP (oxysterol-binding protein) is a key regulator of membrane trafficking through the TGN (trans-Golgi network) and endosomal membranes. We demonstrated recently that Kes1 acts as a sterolregulated rheostat for TGN/endosomal phosphatidylinositol 4-phosphate signalling. Kes1 utilizes its dual lipid-binding activities to integrate endosomal lipid metabolism with TORC1 (target of rapamycin complex 1)-dependent proliferative pathways and transcriptional control of nutrient signalling. ©The Authors Journal compilation ©2012 Biochemical Society.