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    Increased decidual mRNA expression levels of candidate maternal pre-eclampsia susceptibility genes are associated with clinical severity

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    Authors
    Yong, H.
    Murthi, P.
    Borg, A.
    Kalionis, B.
    Moses, Eric
    Brennecke, S.
    Keogh, R.
    Date
    2014
    Type
    Journal Article
    
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    Citation
    Yong, H. and Murthi, P. and Borg, A. and Kalionis, B. and Moses, E. and Brennecke, S. and Keogh, R. 2014. Increased decidual mRNA expression levels of candidate maternal pre-eclampsia susceptibility genes are associated with clinical severity. Placenta. 35 (2): pp. 117-124.
    Source Title
    Placenta
    DOI
    10.1016/j.placenta.2013.11.008
    ISSN
    0143-4004
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/3434
    Collection
    • Curtin Research Publications
    Abstract

    Introduction: Pre-eclampsia (PE) has a familial association, with daughters of women who had PE during pregnancy having more than twice the risk of developing PE themselves. Through genome-wide linkage and genetic association studies in PE-affected families and large population samples, we previously identified the following as positional candidate maternal susceptibility genes for PE; ACVR1, INHA, INHBB, ERAP1, ERAP2, LNPEP, COL4A1 and COL4A2. The aims of this study were to determine mRNA expression levels of previously identified candidate maternal pre-eclampsia susceptibility genes from normotensive and severe PE (SPE) pregnancies and correlate mRNA expression levels with the clinical severity of SPE. Methods: Third trimester decidual tissues were collected from both normotensive (n = 21) and SPE pregnancies (n = 24) and mRNA expression levels were determined by real-time PCR. Gene expression was then correlated with several parameters of clinical severity in SPE. Statistical significance was determined by Mann–Whitney U test and Spearman's Correlation. Results: The data demonstrate significantly increased decidual mRNA expression levels of ACVR1, INHBB, ERAP1, ERAP2, LNPEP, COL4A1 and COL4A2 in SPE (p < 0.05). Increased mRNA expression levels of several genes – INHA, INHBB, COL4A1 and COL4A2 were correlated with earlier onset of PE and earlier delivery of the fetus (p < 0.05). Conclusion: These results suggest altered expression of maternal susceptibility genes may play roles in PE development and the course of disease severity.

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