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    Study of Natural Health Product Adverse Reactions (SONAR): Active Surveillance of Adverse Events Following Concurrent Natural Health product and Prescription Drug Use in Community Pharmacies

    187825_67157_CHARROIS_PLOSOne_2012.pdf (239.5Kb)
    Access Status
    Open access
    Authors
    Vohra, S.
    Cvijovic, K.
    Boon, H.
    Foster, B.
    Jaeger, W.
    LeGatt, D.
    Cembrowski, G.
    Murty, M.
    Tsuyuki, R.
    Barnes, J.
    Charrois, Theresa
    Arnason, J.
    Necyk, C.
    Ware, M.
    Rosychuk, R.
    Date
    2012
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Vohra, Sunita and Cvijovic, Kosta and Boon, Heather and Foster, Brian and Jaeger, Walter and LeGatt, Don and Cembrowski, George and Murty, Mano and Tsuyuki, Ross and Barnes, Joanne and Charrois, Theresa and Arnason, John and Necyk, Candace and Ware, Mark and Rosychuk, Rhonda. 2012. Study of Natural Health Product Adverse Reactions (SONAR): Active Surveillance of Adverse Events Following Concurrent Natural Health product and Prescription Drug Use in Community Pharmacies. PLoS ONE 7 (9): e45196.
    Source Title
    PLoS ONE
    DOI
    10.1371/journal.pone.0045196
    ISSN
    19326203
    Remarks

    Published under Creative Commons Attribution Licence (CC-BY). Under this licence, authors retain ownership of the copyright of the content, but allow download, reuse, reprint, modify, distribute, and/or copy the content as long as the original authors and source are cited. http://www.plos.org/about/open-access/license/

    URI
    http://hdl.handle.net/20.500.11937/34392
    Collection
    • Curtin Research Publications
    Abstract

    Background: Many consumers use natural health products (NHPs) concurrently with prescription medications. As NHP-related harms are under-reported through passive surveillance, the safety of concurrent NHP-drug use remains unknown. To conduct active surveillance in participating community pharmacies to identify adverse events related to concurrent NHP-prescription drug use. Methodology/Principal Findings: Participating pharmacists asked individuals collecting prescription medications about (i) concurrent NHP/drug use in the previous three months and (ii) experiences of adverse events. If an adverse event was identified and if the patient provided written consent, a research pharmacist conducted a guided telephone interview to gather additional information after obtaining additional verbal consent and documenting so within the interview form. Over a total of 112 pharmacy weeks, 2615 patients were screened, of which 1037 (39.7%; 95% CI: 37.8% to 41.5%) reported concurrent NHP and prescription medication use. A total of 77 patients reported a possible AE (2.94%; 95% CI: 2.4% to 3.7%), which represents 7.4% of those using NHPs and prescription medications concurrently (95%CI: 6.0% to 9.2%). Of 15 patients available for an interview, 4 (26.7%: 95% CI: 4.3% to 49.0%) reported an AE that was determined to be “probably” due to NHP use. Conclusions/Significance: Active surveillance markedly improves identification and reporting of adverse events associated with concurrent NHP-drug use. Although not without challenges, active surveillance is feasible and can generate adverse event data of sufficient quality to allow for meaningful adjudication to assess potential harms.

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