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dc.contributor.authorNg, P.
dc.contributor.authorOng, A.
dc.contributor.authorGale, L.
dc.contributor.authorDass, Crispin
dc.date.accessioned2017-01-30T13:44:56Z
dc.date.available2017-01-30T13:44:56Z
dc.date.created2016-10-26T19:30:21Z
dc.date.issued2016
dc.identifier.citationNg, P. and Ong, A. and Gale, L. and Dass, C. 2016. Treatment of bone disorders with parathyroid hormone: Success and pitfalls. Pharmazie. 71 (8): pp. 427-433.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/34660
dc.identifier.doi10.1691/ph.2016.6008
dc.description.abstract

Bone diseases such as osteoporosis, osteoarthritis, bone tumours and bone fractures are rather common and not just in the elderly. Parathyroid hormone (PTH) is responsible for maintaining calcium homeostasis, increasing bone mineral density (BMD), increasing cortical and trabecular bone thickness and thus increasing bone strength. Teriparatide (PTH 1-34) has the same effects as endogenous PTH and is pharmacologically used to treat bone diseases such as osteoporosis, osteoarthritis, bone fractures and bone tumours. This review discusses how PTH 1-34 plays a role in managing bone diseases. Clinical studies have shown that short or intermittent dosing of PTH 1-34 has minimal adverse effects, while long-term dosing (over two years) has been linked to de novo osteoarthritis and bone deformation. Currently PTH therapy is only approved in the treatment of post-menopausal osteoporosis, however it is also proven to have effects in treating osteoarthritis, bone tumours and bone fractures. If the patient undergoing therapy is closely monitored, the major pitfalls are very unlikely to take place, thus it is highly recommended that patients be closely monitored by a medical practitioner.

dc.publisherGovi Verlag Pharmazeutischer Verlag GmbH
dc.titleTreatment of bone disorders with parathyroid hormone: Success and pitfalls
dc.typeJournal Article
dcterms.source.volume71
dcterms.source.number8
dcterms.source.startPage427
dcterms.source.endPage433
dcterms.source.issn0031-7144
dcterms.source.titlePharmazie
curtin.departmentSchool of Pharmacy
curtin.accessStatusFulltext not available


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