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dc.contributor.authorShanahan, R.
dc.contributor.authorReen, F.
dc.contributor.authorCano, R.
dc.contributor.authorO'Gara, Fergal
dc.contributor.authorMcGlacken, G.
dc.identifier.citationShanahan, R. and Reen, F. and Cano, R. and O'Gara, F. and McGlacken, G. 2017. The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa. Organic and Biomolecular Chemistry. 15 (2): pp. 306-310.

The 'perfect storm' of increasing bacterial antibiotic resistance and a decline in the discovery of new antibiotics, has made it necessary to search for new and innovative strategies to treat bacterial infections. Interruption of bacterial cell-to-cell communication signalling (Quorum Sensing), thus neutralizing virulence in pathogenic bacteria, is a growing area. 2-Alkyl-4-quinolones, HHQ and PQS, play a key role in the quorum sensing circuitry of P. aeruginosa. We report a new set of isosteres of 2-heptyl-6-nitroquinolin-4-one, with alterations at C-3, and evaluate the key structural requirements for agonistic and antagonistic activity in Pseudomonas aeruginosa.

dc.publisherRoyal Society of Chemistry
dc.titleThe requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa
dc.typeJournal Article
dcterms.source.titleOrganic and Biomolecular Chemistry
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available

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