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    CD4+ and CD8+ T cells expressing FoxP3 in HIV-infected patients are phenotypically distinct and influenced by disease severity and antiretroviral therapy

    Access Status
    Open access via publisher
    Authors
    Lim, A.
    French, M.
    Price, Patricia
    Date
    2009
    Type
    Journal Article
    
    Metadata
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    Citation
    Lim, A. and French, M. and Price, P. 2009. CD4+ and CD8+ T cells expressing FoxP3 in HIV-infected patients are phenotypically distinct and influenced by disease severity and antiretroviral therapy. JAIDS: Journal of Acquired Immune Deficiency Syndromes. 51 (3): pp. 248-257.
    Source Title
    JAIDS: Journal of Acquired Immune Deficiency Syndromes
    DOI
    10.1097/QAI.0b013e3181a74fad
    ISSN
    1525-4135
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/34779
    Collection
    • Curtin Research Publications
    Abstract

    OBJECTIVES: Forkhead box P3 (FoxP3) is critical for the development of CD4 regulatory T (Treg) cells and is a useful marker to identify this population. Recently, expression of FoxP3 was reported in human CD8 T cells from the blood of untreated HIV-infected individuals. We assessed whether FoxP3 expression in CD8 T cells is associated with suppressive potential and/or with HIV-associated immune activation. METHODS: FoxP3CD8 T cells in non-HIV donors and in untreated and treated HIV-infected patients were identified by flow cytometry, then examined for coexpression of other Treg cell-associated markers [cytotoxic T lymphocyte-associated antigen (CTLA)-4, GITR, and CD45RO], markers of activation [HLA-DR, Ki-67, and programmed death (PD)-1], and markers of senescence (CD57 without CD28). RESULTS: Similar proportions of FoxP3-expressing CD4 and CD8 T cells coexpressed HLA-DR and Ki-67. However, compared with FoxP3CD4 cells, FoxP3CD8 cells expressed less CTLA-4, CD28, and CD45RO but more PD-1 and CD57. FoxP3-expressing CD4 and CD8 cells from untreated patients exhibited higher expression of HLA-DR, Ki-67, and PD-1 compared with non-HIV donors and treated patients. CONCLUSIONS: FoxP3CD8 T cells are phenotypically distinct from FoxP3CD4 and FoxP3CD8 T cells. Expression of FoxP3 is associated with cellular activation in both CD4 and CD8 T cells. © 2009 by Lippincott Williams & Wilkins.

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