Dysregulation of granulosal bone morphogenetic protein receptor 1B density is associated with reduced ovarian reserve and the age-related decline in human fertility
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Reproductive ageing is linked to the depletion of ovarian primordial follicles, which causes an irreversible change to ovarian cellular function and the capacity to reproduce. The current study aimed to profile the expression of bone morphogenetic protein receptor, (BMPR1B) in 53 IVF patients exhibiting different degrees of primordial follicle depletion. The granulosa cell receptor density was measured in 403 follicles via flow cytometry. A decline in BMPR1B density occurred at the time of dominant follicle selection and during the terminal stage of folliculogenesis in the 23-30 y good ovarian reserve patients. The 40+ y poor ovarian reserve patients experienced a reversal of this pattern. The results demonstrate an association between age-induced depletion of the ovarian reserve and BMPR1B receptor density at the two critical time points of dominant follicle selection and pre-ovulatory follicle maturation. Dysregulation of BMP receptor signalling may inhibit the normal steroidogenic differentiation required for maturation in older patients.
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Infertility and ovarian follicle reserve depletion are associated with dysregulation of the FSH and LH receptor density in human antral folliclesRegan, Sheena; Knight, P.; Yovich, John; Stanger, J.; Leung, Y.; Arfuso, Frank; Dharmarajan, Arunasalam; Almahbobi, Ghanim (2017)The low take-home baby rate in older women in Australia (5.8%) undergoing IVF is linked to the depletion of the ovarian reserve of primordial follicles. Oocyte depletion causes an irreversible change to ovarian function. ...
The effect of ovarian reserve and receptor signalling on granulosa cell apoptosis during human follicle developmentRegan, S.; Knight, P.; Yovich, John; Stanger, J.; Leung, Y.; Arfuso, Frank; Almahbobi, Ghanim; Dharmarajan, Arunasalam (2017)The poor oocyte quality in older women has previously been linked to the depletion of the ovarian reserve of primordial follicles and an increase in granulosal apoptosis. Granulosa cells were collected from 198 follicles ...
Regan, S.; Knight, P.; Yovich, John; Leung, Y.; Arfuso, Frank; Dharmarajan, Arunasalam (2018)© 2018 Elsevier Inc. Primordial germ cells migrate to the fetal gonads and proliferate during gestation to generate a fixed complement of primordial follicles, the so-called ovarian reserve. Primordial follicles comprise ...