A new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines
| dc.contributor.author | Dolzhenko, Anton | |
| dc.contributor.author | Pastorin, G. | |
| dc.contributor.author | Dolzhenko, A. | |
| dc.contributor.author | Chui, W. | |
| dc.date.accessioned | 2017-01-30T13:47:00Z | |
| dc.date.available | 2017-01-30T13:47:00Z | |
| dc.date.created | 2011-08-17T20:01:14Z | |
| dc.date.issued | 2009 | |
| dc.identifier.citation | Dolzhenko, Anton and Pastorin, G. and Dolzhenko, A. and Chui, W. 2009. A new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines. Tetrahedron Letters. 50 (40): pp. 5617-5621. | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/35003 | |
| dc.identifier.doi | 10.1016/j.tetlet.2009.07.113 | |
| dc.description.abstract |
A practical synthesis of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines, which are key intermediates inthe preparation of adenosine receptor antagonists, is developed. The method allows introduction of avariety of aryl substituents at position 2 of the pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine systemvia cyclocondensation of 5-amino-4-iminopyrazolo[3,4-d]pyrimidine with benzaldehydes accompaniedwith oxidation by iodobenzene diacetate. Some unexpected reactions are observed and the structuresof the products are confirmed using NMR spectroscopy and X-ray crystallography. | |
| dc.publisher | Elsevier Science Limted | |
| dc.title | A new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines | |
| dc.type | Journal Article | |
| dcterms.source.volume | 50 | |
| dcterms.source.number | 40 | |
| dcterms.source.startPage | 5617 | |
| dcterms.source.endPage | 5621 | |
| dcterms.source.issn | 0040-4039 | |
| dcterms.source.title | Tetrahedron Letters | |
| curtin.department | School of Pharmacy | |
| curtin.accessStatus | Fulltext not available |