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    Predictive mutational bioinformatic analysis of variation in the skin and wool associated corneodesmosin (CDSN) gene in sheep

    Access Status
    Fulltext not available
    Authors
    Siva Subramaniam, Nitthiya
    Morgan, Eleanor
    Bottomley, Steve
    Tay, S.
    Gregg, Keith
    Lee, Chee Yang
    Wetherall, John
    Groth, David
    Date
    2012
    Type
    Journal Article
    
    Metadata
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    Citation
    Siva Subramaniam, Nitthiya and Morgan, Eleanor and Bottomley, Steven and Tay, Sharon and Gregg, Keith and Lee, Chee Yang and Wetherall, John and Groth, David. 2012. Predictive mutational bioinformatic analysis of variation in the skin and wool associated corneodesmosin (CDSN) gene in sheep. Animal Science Journal. 83 (5): pp. 386-393.
    Source Title
    Animal Science Journal
    DOI
    10.1111/j.1740-0929.2011.00975.x
    ISSN
    13443941
    URI
    http://hdl.handle.net/20.500.11937/35174
    Collection
    • Curtin Research Publications
    Abstract

    Corneodesmosin (CDSN) is an important component of the desmosome in the epidermal cornified stratum and inner root sheath of hair follicles. DNA from a sheep BAC clone previously identified by us to contain CDSN was PCR amplified using cattle-derived primers and the product sequenced. A region of 4579 bp containing CDSN was shown to contain two exons separated by one intron and spanning 3683 bp. The DNA encodes a predicted protein of 546 amino acids. Phylogenetic analysis shows that sheep CDSN falls within a clade containing cattle and other ruminant-like species. Comparison of sequences generated from 12 unrelated merino sheep and the International Sheep Genome Consortium (ISGC) data identified 58 single nucleotide polymorphisms (SNPs) within the 4579 bp region of which 16 are contained within coding sequences (1 in 80 bp). The SNPs identified in this study will add to the Major Histocompatibility Complex (MHC) SNP panel, which will allow extensive haplotyping of the sheep MHC in future studies.

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