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dc.contributor.authorNewsholme, Philip
dc.contributor.authorKrause, M.
dc.contributor.editorIsmail Laher
dc.date.accessioned2017-01-30T13:48:44Z
dc.date.available2017-01-30T13:48:44Z
dc.date.created2015-05-22T08:32:01Z
dc.date.issued2014
dc.identifier.citationNewsholme, P. and Krause, M. 2014. Diet, Obesity, and Reactive Oxygen Species – Implications for Diabetes and Aging. In Systems Biology of Free Radicals and Anti-Oxidants, ed. I. Laher, 3361-3374. Berlin: Springer Verlag.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/35273
dc.identifier.doi10.1007/978-3-642-30018-9_152
dc.description.abstract

An increase in reactive oxygen species (ROS) and a decrease in endogenous antioxidant defense mechanisms are observed in both aging and diabetes. The mechanisms driving an increase in ROS are generally associated with low-grade inflammation in obesity, diabetes and aging. The sources of ROS, sources of antioxidants, and the impact on mitochondrial function are described in this chapter and the relevance of imbalances in favor of ROS generation to loss of muscle function in both aging and diabetes are described in more detail.

dc.publisherSpringer Verlag
dc.subjectReactive nitrogen species
dc.subjectReactive oxygen species
dc.subjectOxidative stress
dc.subjectDiet and exercise intervention
dc.titleDiet, Obesity, and Reactive Oxygen Species – Implications for Diabetes and Aging
dc.typeBook Chapter
dcterms.source.startPage3361
dcterms.source.endPage3374
dcterms.source.titleSystems Biology of Free Radicals and Anti-Oxidants
dcterms.source.isbn978-3-642-30017-2
dcterms.source.placeBerlin
dcterms.source.chapter148
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available


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