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dc.contributor.authorStewart, Louise
dc.contributor.authorHolman, C. D'Arcy
dc.contributor.authorFinn, Judith
dc.contributor.authorPreen, David
dc.contributor.authorHart, Roger
dc.date.accessioned2017-01-30T13:49:46Z
dc.date.available2017-01-30T13:49:46Z
dc.date.created2014-03-27T20:00:58Z
dc.date.issued2013
dc.identifier.citationStewart, Louise and Holman, C. D'Arcy and Finn, Judith and Preen, David and Hart, Roger. 2013. Association between in-vitro fertilization, birth and melanoma. Melanoma Research. 23 (6): pp. 489-495.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/35444
dc.identifier.doi10.1097/CMR.0000000000000019
dc.description.abstract

A link between reproductive hormones and melanoma has long been suspected, and has been examined for numerous hormonal exposures, but the association between in-vitro fertilization (IVF) and melanoma has not been studied in depth. We used whole-population linked hospital and registry data to carry out a cohort study of women aged 20–44 years seeking hospital investigation and treatment for infertility in Western Australia from 1982 to 2002 with follow-up to 2010. The cohort comprised a total of 21 604 women followed for an average of 17.2 years. Of these, 7524 had IVF treatment, 14 870 gave birth and 149 women were diagnosed with an incident invasive melanoma. Using Cox regression analysis, we estimated hazard ratios (HRs) for melanoma associated with IVF and parity. Women who had IVF and gave birth had an increased rate of invasive melanoma compared with women who had IVF and remained nulliparous (HR 3.61; 95% confidence interval 1.79–7.26).There was little or no increase in the rate of invasive melanoma associated with giving birth in women who had non-IVF infertility treatment (HR 1.39; 95% confidence interval 0.88–2.20). These results suggest an association between reproductive factors and melanoma in the subgroup of women undergoing IVF treatment.

dc.publisherLippincott Williams & Wilkins
dc.subjectin-vitro fertilization
dc.subjectparity
dc.subjectbirth
dc.subjectepidemiology
dc.subjectmelanoma
dc.subjectcohort studies
dc.titleAssociation between in-vitro fertilization, birth and melanoma
dc.typeJournal Article
dcterms.source.volume23
dcterms.source.number6
dcterms.source.startPage489
dcterms.source.endPage495
dcterms.source.issn1473-5636
dcterms.source.titleMelanoma Research
curtin.note

This is a non-final version of an article published in final form in: Stewart, Louise and Holman, C. D'Arcy and Finn, Judith and Preen, David and Hart, Roger. 2013. Association between in-vitro fertilization, birth and melanoma. Melanoma Research. 23 (6): pp. 489-495.

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curtin.accessStatusOpen access


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