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dc.contributor.authorHuxley, Rachel
dc.contributor.authorLopez, F.
dc.contributor.authorMacLehose, R.
dc.contributor.authorEckfeldt, J.
dc.contributor.authorCouper, D.
dc.contributor.authorLeiendecker-Foster, C.
dc.contributor.authorHoogeveen, R.
dc.contributor.authorChen, L.
dc.contributor.authorSoliman, E.
dc.contributor.authorAgarwal, S.
dc.contributor.authorAlonso, A.
dc.date.accessioned2017-01-30T13:49:59Z
dc.date.available2017-01-30T13:49:59Z
dc.date.created2016-02-04T19:30:29Z
dc.date.issued2013
dc.identifier.citationHuxley, R. and Lopez, F. and MacLehose, R. and Eckfeldt, J. and Couper, D. and Leiendecker-Foster, C. and Hoogeveen, R. et al. 2013. Novel Association between Plasma Matrix Metalloproteinase-9 and Risk of Incident Atrial Fibrillation in a Case-Cohort Study: The Atherosclerosis Risk in Communities Study. PLoS ONE. 8 (3): pp. e59052.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/35490
dc.identifier.doi10.1371/journal.pone.0059052
dc.description.abstract

Background: Previous cross-sectional studies have suggested that biomarkers of extracellular matrix remodelling are associated with atrial fibrillation (AF), but no prospective data have yet been published. Hence, we examine whether plasma matrix metalloproteinases (MMP) and their inhibitors are related to increased risk of incident AF. Methods: We used a case-cohort design in the context of the prospective Atherosclerosis Risk in Communities (ARIC) study. From 13718 eligible men and women free from AF in 1990-92, we selected a stratified random sample of 500 individuals without and 580 with incident AF over a mean follow-up of 11.8 years. Using a weighted proportional hazards regression model, the relationships between MMP-1, MMP-2, MMP-9, tissue inhibitor of matrix metalloproteinase (TIMP)-1, TIMP-2 and C-terminal propeptide of collagen type-I with incident AF were examined after adjusting for confounders. Results: In models adjusted for age, sex and race, all biomarkers were associated with AF, but only the relationship between plasma MMP-9 remained significant in the fully-adjusted model: each one standard deviation increase in MMP-9 was associated with 27% (95% Confidence Interval: 7% to 50%) increase in risk of AF with no evidence of an interaction with race or sex. Individuals with above mean levels of MMP-9 were more likely to be male, white and current smokers. Conclusions: The findings suggest that elevated levels of MMP-9 are independently associated with increased risk of AF. However, given the lack of specificity of MMP-9 to atrial tissue, it remains to be determined whether the observed relationship reflects the impact of atrial fibrosis or more generalized fibrosis on risk of incident AF. © 2013 Huxley et al.

dc.titleNovel Association between Plasma Matrix Metalloproteinase-9 and Risk of Incident Atrial Fibrillation in a Case-Cohort Study: The Atherosclerosis Risk in Communities Study
dc.typeJournal Article
dcterms.source.volume8
dcterms.source.number3
dcterms.source.titlePLoS ONE
curtin.note

This open access article is distributed under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

curtin.departmentSchool of Public Health
curtin.accessStatusOpen access


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