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dc.contributor.authorLam, Virginie
dc.contributor.authorAlbrecht, Matthew
dc.contributor.authorTakechi, Ryu
dc.contributor.authorPrasopsang, P.
dc.contributor.authorLee, Ya Ping
dc.contributor.authorFoster, Jonathan
dc.contributor.authorMamo, John
dc.identifier.citationLam, V. and Albrecht, M. and Takechi, R. and Prasopsang, P. and Lee, Y.P. and Foster, J. and Mamo, J. 2015. Serum 25-hydroxyvitamin D is associated with reduced verbal episodic memory in healthy, middle-aged and older adults. European Journal of Nutrition. [In Press].

Background - There is increasing evidence supporting an association of higher serum vitamin D concentration with better cognitive performance in older individuals. However, to date, consideration of the putative association between vitamin D and cognition has been based principally on studies investigating clinical participant samples manifesting vitamin D deficiency, particularly in older people. Moreover, relationships between vitamin D and cognition are typically not considered in the context of counter-regulatory calcium-modulating hormones or calcium homeostasis. Objective - Serum vitamin D/bioactive (ionised) calcium/parathyroid hormone homeostasis was considered in the context of cognitive performance in healthy, middle-aged and older individuals. Design - A cross-sectional sample of 179 participants between the ages of 47–84 years was recruited for this study (114 females, 65 males). Participants provided fasting blood samples for analysis of serum 25-hydroxyvitamin D levels, ionised calcium (iCa) and parathyroid hormone (PTH) and completed cognitive measures of verbal episodic learning and memory. Results - Serum 25-hydroxyvitamin D concentrations were negatively associated (with and without covariates of age, gender, depression and NART scores, iCa, and PTH) with measures of verbal episodic learning and memory, in particular with trial 5 of the Rey Auditory Verbal Learning Test (RAVLT) and long-delay free recall on the RAVLT. Conclusion - Overall, the findings from this study suggest an association between higher vitamin D status and poorer performance on verbal episodic memory in middle-aged and older individuals with normal vitamin D–calcium–PTH homeostasis. Despite requiring replication in other participant samples, this is a potentially important finding as it indicates that it may not be beneficial from a cognitive perspective to provide vitamin D supplements in individuals with already adequate vitamin D status.

dc.publisherSpringer Medizin
dc.subjectSerum 25-hydroxyvitamin D
dc.subjectVitamin D
dc.subjectVerbal episodic memory
dc.subjectParathyroid hormone
dc.subjectIonised calcium
dc.titleSerum 25-hydroxyvitamin D is associated with reduced verbal episodic memory in healthy, middle-aged and older adults
dc.typeJournal Article
dcterms.source.titleEuropean Journal of Nutrition
curtin.departmentSchool of Public Health
curtin.accessStatusFulltext not available

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