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    Primary haemostasis: Newer insights

    Access Status
    Open access via publisher
    Authors
    Berndt, Michael
    Metharom, Pat
    Andrews, R.
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Berndt, M. and Metharom, P. and Andrews, R. 2014. Primary haemostasis: Newer insights. Haemophilia. 20 (S4): pp. 15-22.
    Source Title
    Haemophilia
    DOI
    10.1111/hae.12427
    ISSN
    1351-8216
    Faculty
    Faculty of Health Sciences
    URI
    http://hdl.handle.net/20.500.11937/36093
    Collection
    • Curtin Research Publications
    Abstract

    At the same time as biophysical and omics approaches are drilling deeper into the molecular details of platelets and other blood cells, as well as their receptors and mechanisms of regulation, there is also an increasing awareness of the functional overlap between human vascular systems. Together, these studies are redefining the intricate networks linking haemostasis and thrombosis with inflammation, infectious disease, cancer/metastasis and other vascular pathophysiology. The focus of this state-of-the-art review is some of the newer advances relevant to primary haemostasis. Of particular interest, platelet-specific primary adhesion-signalling receptors and associated activation pathways control platelet function in flowing blood and provide molecular links to other systems. Platelet glycoprotein (GP)Iba of the GPIb-IX-V complex and GPVI not only initiate platelet aggregation and thrombus formation by primary interactions with von Willebrand factor and collagen, respectively, but are also involved in coagulation, leucocyte engagement, bacterial or viral interactions, and are relevant as potential risk markers in a range of human diseases. Understanding these systems in unprecedented detail promises significant advances in evaluation of individual risk, in new diagnostic or therapeutic possibilities and in monitoring the response to drugs or other treatment. © 2014 John Wiley & Sons Ltd.

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