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    Pipeline pharmacogenetics: A novel approach to integrating pharmacogenetics into drug development

    Access Status
    Fulltext not available
    Authors
    Akkari, Patrick
    Swanson, T.
    Crenshaw, D.
    Grossman, I.
    Sundseth, S.
    Burns, D.
    Roses, A.
    Date
    2009
    Type
    Journal Article
    
    Metadata
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    Citation
    Akkari, P. and Swanson, T. and Crenshaw, D. and Grossman, I. and Sundseth, S. and Burns, D. and Roses, A. 2009. Pipeline pharmacogenetics: A novel approach to integrating pharmacogenetics into drug development. Current Pharmaceutical Design. 15 (32): pp. 3754-3763.
    Source Title
    Current Pharmaceutical Design
    DOI
    10.2174/138161209789649538
    ISSN
    1381-6128
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/36105
    Collection
    • Curtin Research Publications
    Abstract

    There has been a decline in the number of new drugs registered over the past decade and regulatory concerns for safety as well as payer concerns for efficacy have focused attention on stratified medicine. Integration of pharmacogenetics into the drug development pipeline will contribute to the development of new stratified drugs. We describe here the concept of pipeline pharmacogenetics and its application throughout the phases of drug discovery. Pipeline pharmacogenetics enables the evaluation of the genetic contribution to safety potentially lowering barriers to registration as well as providing rationale for efficacy and enabling co-development of genetic in vitro diagnostics. © 2009 Bentham Science Publishers Ltd.

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