Pipeline pharmacogenetics: A novel approach to integrating pharmacogenetics into drug development
MetadataShow full item record
There has been a decline in the number of new drugs registered over the past decade and regulatory concerns for safety as well as payer concerns for efficacy have focused attention on stratified medicine. Integration of pharmacogenetics into the drug development pipeline will contribute to the development of new stratified drugs. We describe here the concept of pipeline pharmacogenetics and its application throughout the phases of drug discovery. Pipeline pharmacogenetics enables the evaluation of the genetic contribution to safety potentially lowering barriers to registration as well as providing rationale for efficacy and enabling co-development of genetic in vitro diagnostics. © 2009 Bentham Science Publishers Ltd.
Showing items related by title, author, creator and subject.
Can population differences in chemotherapy outcomes be inferred from differences in pharmacogenetic frequenciesLoh, M.; Chua, D.; Yao, Y.; Soo, R.; Garrett, K.; Zeps, Nikolajs; Platell, C.; Minamoto, T.; Kawakami, K.; Iacopetta, B.; Soong, R. (2013)Inter-ethnic differences in drug handling and frequencies of pharmacogenetic variants are increasingly being characterized. In this study, we systematically assessed the feasibility of inferring ethnic trends in chemotherapy ...
Sullivan, Michael R. (2003)This dissertation applies a commercial flow simulation software package together with common signal processing techniques to the task of accurately detecting leakage in a large commercial gas pipeline. The techniques ...
Vibration-based structural health monitoring of offshore pipelines: Numerical and experimental studyBao, C.; Hao, Hong; Li, Z. (2013)The world economy is heavily dependent upon an extensive network of pipelines for energy sources transmission. Because the consequence of pipeline failure could be disastrous both economically and environmentally, it is ...