Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Artemisinin-Naphthoquine Combination Therapy for Uncomplicated Pediatric Malaria: a Pharmacokinetic Study

    Access Status
    Open access via publisher
    Authors
    Batty, Kevin
    Salman, Sam
    Moore, Brioni
    Benjamin, John
    Lee, Sook Ting
    Page-Sharp, Madhu
    Pitus, Nolene
    Ilett, Kenneth
    Mueller, Ivo
    Hombhanje, Francis
    Siba, Peter
    Davis, Timothy
    Date
    2012
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Batty, Kevin and Salman, Sam and Moore, Brioni and Benjamin, John and Lee, Sook Ting and Page-Sharp, Madhu and Pitus, Nolene and Ilett, Kenneth and Mueller, Ivo and Hombhanje, Francis and Siba, Peter and Davis, Timothy. 2012. Artemisinin-Naphthoquine Combination Therapy for Uncomplicated Pediatric Malaria: a Pharmacokinetic Study. Antimicrobial Agents and Chemotherapy 56 (5): pp. 2472-2484.
    Source Title
    Antimicrobial Agents and Chemotherapy
    DOI
    10.1128/AAC.06250-11
    ISSN
    0066-4804
    URI
    http://hdl.handle.net/20.500.11937/36181
    Collection
    • Curtin Research Publications
    Abstract

    Artemisinin-naphthoquine (ART-NQ) is a coformulated antimalarial therapy marketed as a single-dose treatment in Papua New Guinea and other tropical countries. To build on limited knowledge of the pharmacokinetic properties of the components, especially the tetra-aminoquinoline NQ, we studied ART-NQ disposition in Papua New Guinea children aged 5 to 12 years with uncomplicated malaria, comparing a single dose (15 and 6 mg/kg of body weight) administered with water (group 1; n = 13), a single dose (22 and 9 mg/kg) with milk (group 2) (n = 17), and two daily doses of 22 and 9 mg/kg with water (group 3; n = 16). The plasma NQ concentration was assayed by high-performance liquid chromatography, and the plasma ART concentration was assayed using liquid chromatography-mass spectrometry. Population-based multicompartment pharmacokinetic models for NQ and ART were developed. NQ disposition was best characterized by a three-compartment model with a mean absorption half-life (t1/2) of 1.0 h and predicted median maximum plasma concentrations that ranged as high as 57 μg/liter after the second dose in group 3. The mean NQ elimination t1/2 was 22.8 days; clearance relative to bioavailability (CL/F) was 1.1 liters/h/kg; and volume at steady state relative to bioavailability (Vss/F) was 710 liters/kg. Administration of NQ with fat (8.5 g; 615 kJ) versus water was associated with 25% increased bioavailability. ART disposition was best characterized by a two-compartment model with a mean CL/F (4.1 liters/h/kg) and V/F (21 liters/kg) similar to those of previous studies. There was a 77% reduction in the bioavailability of the second ART dose (group 3). NQ has pharmacokinetic properties that confirm its potential as an artemisinin partner drug for treatment of uncomplicated pediatric malaria.

    Related items

    Showing items related by title, author, creator and subject.

    • Pharmacokinetic properties of single-dose primaquine in Papua New Guinean children: Feasibility of abbreviated high-dose regimens for radical cure of vivax malaria
      Moore, Brioni; Salman, S.; Benjamin, J.; Page-Sharp, Madhu; Robinson, L.; Waita, E.; Batty, Kevin; Siba, P.; Mueller, I.; Davis, T.; Betuela, I. (2014)
      Since conventional 14-day primaquine (PMQ) radical cure of vivax malaria is associated with poor compliance and as total dose, not therapy duration, determines efficacy, a preliminary pharmacokinetic study of two doses ...
    • Population pharmacokinetics, tolerability, and safety of dihydroartemisinin-piperaquine and sulfadoxine-pyrimethamine-piperaquine in pregnant and nonpregnant Papua New Guinean women
      Benjamin, J.; Moore, B.; Salman, S.; Page-Sharp, Madhu; Tawat, S.; Yadi, G.; Lorry, L.; Siba, P.; Batty, Kevin; Robinson, L.; Mueller, I.; Davis, T. (2015)
      The tolerability, safety, and disposition of dihydroartemisinin (DHA) and piperaquine (PQ) were assessed in 32 pregnant (second/third trimester) and 33 nonpregnant Papua New Guinean women randomized to adult treatment ...
    • Pharmacokinetic Properties of Conventional and Double-Dose Sulfadoxine-Pyrimethamine Given as Intermittent Preventive Treatment in Infancy
      Salman, S.; Griffin, S.; Kose, K.; Pitus, N.; Winmai, J.; Moore, Brioni; Siba, P.; Ilett, K.; Mueller, I.; Davis, T. (2011)
      Intermittent preventive treatment in infancy (IPTi) entails routine administration of antimalarial treatment doses at specified times in at-risk infants. Sulfadoxine-pyrimethamine (SDX/PYR) is a combination that has been ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.