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dc.contributor.authorTacar, O.
dc.contributor.authorDass, Crispin
dc.date.accessioned2017-01-30T13:54:21Z
dc.date.available2017-01-30T13:54:21Z
dc.date.created2014-04-16T20:00:56Z
dc.date.issued2013
dc.identifier.citationTacar, Oktay and Dass, Crispin R. 2013. Doxorubicin-induced death in tumour cells and cardiomyocytes: is autophagy the key to improving future clinical outcomes? Journal of Pharmacy and Pharmacology. 65 (11): pp. 1577-1589.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/36210
dc.identifier.doi10.1111/jphp.12144
dc.description.abstract

Objectives: Doxorubicin, a commonly used frontline chemotherapeutic agent for cancer, is not without side-effects. The original thinking that the drug causes necrosis in tumours has largely given way to its link with apoptosis over the past two decades. Key findings: More recently, major biomarkers such as AMPK, p53 and Bcl-2 have been identified as important to apoptosis induction by doxorubicin. It is Bcl-2 and its interaction with Beclin-1 that has refocussed research attention on doxorubicin, albeit this time for its ability to induce autophagy. Autophagy can be either anticancerous or procancerous however, so it is critical that the reasons for which cancer cells undergo this type of cell biological event be clearly identified for future exploitation. Summary: Taking a step back from treating patients with large doses of doxorubicin, which causes toxicity to the heart amongst other organs, and further research with this drug's molecular signalling in not only neoplastic but normal cells, may indeed redefine the way doxorubicin is used clinically and potentially lead to better neoplastic disease management.

dc.publisherJohn Wiley & Sons Ltd.
dc.subjectcell death
dc.subjectdoxorubicin
dc.subjectcardiotoxicity
dc.subjectautophagy
dc.subjectcancer
dc.titleDoxorubicin-induced death in tumour cells and cardiomyocytes: is autophagy the key to improving future clinical outcomes?
dc.typeJournal Article
dcterms.source.volume65
dcterms.source.number11
dcterms.source.startPage1577
dcterms.source.endPage1589
dcterms.source.issn0022-3573
dcterms.source.titleJournal of Pharmacy and Pharmacology
curtin.department
curtin.accessStatusOpen access via publisher


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