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Microneedle Enhanced Delivery of Cosmeceutically Relevant Peptides in Human Skin

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Open access
Authors
Mohammed, Yousuf
Yamada, M.
Lin, L.
Grice, J.
Roberts, M.
Raphael, A.
Benson, Heather
Prow, T.
Date
2014
Type
Journal Article

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Mohammed, Y. and Yamada, M. and Lin, L. and Grice, J. and Roberts, M. and Raphael, A. and Benson, H. et al. 2014. Microneedle Enhanced Delivery of Cosmeceutically Relevant Peptides in Human Skin. PLoS ONE. 9 (7): Article ID e101956.
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PLoS ONE
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School of Pharmacy
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This article is published under the Open Access publishing model and distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ Please refer to the licence to obtain terms for any further reuse or distribution of this work.

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Abstract

Peptides and proteins play an important role in skin health and well-being. They are also found to contribute to skin aging and melanogenesis. Microneedles have been shown to substantially enhance skin penetration and may offer an effective means of peptide delivery enhancement. The aim of this investigation was to assess the influence of microneedles on the skin penetration of peptides using fluorescence imaging to determine skin distribution. In particular the effect of peptide chain length (3, 4, 5 amino acid chain length) on passive and MN facilitated skin penetration was investigated. Confocal laser scanning microscopy was used to image fluorescence intensity and the area of penetration of fluorescently tagged peptides. Penetration studies were conducted on excised full thickness human skin in Franz type diffusion cells for 1 and 24 hours. A 2 to 22 fold signal improvement in microneedle enhanced delivery of melanostatin, rigin and pal-KTTKS was observed. To our knowledge this is the first description of microneedle enhanced skin permeation studies on these peptides.