Growth hormone supplementation improves implantation and pregnancy productivity rates for poor-prognosis patients undertaking IVF
MetadataShow full item record
In a sequential crossover study of IVF conducted from 2002 to 2006, growth hormone (GH) supplementation was assessed in poor-prognosis patients, categorized on the basis of past failure to conceive (mean 3.05 cycles) due to low response to high-dose stimulation (<3 metaphase II oocytes) or poor-quality embryos. Pregnancy rates in both fresh and frozen transfer cycles and the total productivity rates (fresh and frozen pregnancies per egg collection) were compared. In all, 159 patients had 488 treatment cycles: 221 with GH and 241 without GH. These cycles were also compared with 1572 uncategorized cycles from the same period. GH co-treatment significantly improved the clinical pregnancy rate per fresh transfer (P < 0.001) as well as per frozen-thawed embryo derived from GH cycles (P < 0.05) creating a highly significant productivity rate (P < 0.001). The effect was significant across all age groups, especially in younger patients, and was independent of stimulation modality or number of transfers. GH cycles resulted in significantly more babies delivered per transfer than non-GH cycles (20% versus 7%; P < 0.001) although less than the uncategorized cycles (53%). The data uniquely show that the effect of GH is directed at oocyte and subsequent embryo quality. © 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
Showing items related by title, author, creator and subject.
Follicle recruitment determines IVF productivity rate via the number of embryos frozen and subsequent transfersStanger, J.; Yovich, John (2013)IVF productivity rate is an index defined as the sum of all live births from either fresh or frozen embryo transfers arising from a single oocyte collection. This retrospective analysis over 9 continuous years used this ...
Single-centre retrospective analysis of growth hormone supplementation in IVF patients classified as poor-prognosisKeane, Kevin; Yovich, John; Hamidi, A.; Hinchliffe, P.; Dhaliwal, S. (2017)© Article author(s) 2017. Background Patients undergoing in vitro fertilisation (IVF) receive various adjuvant therapies in order to enhance success rates, but the true benefit is actively debated. Growth hormone (GH) ...
The impact of lifestyle factors on the clinical outcomes of in vitro fertilisation-embryo transfer (IVF) treatmentJoesbury, Karen Ann (2003)Objectives: To determine the effect of female and male cigarette smoking, caffeine and alcohol consumption, stress and indicators of dietary status on the clinical outcomes of NF treatment. Design: Prospective cohort ...