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    New insight into the intracellular roles of class II phosphoinositide 3-kinases

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    Authors
    Maffucci, T.
    Falasca, Marco
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Maffucci, T. and Falasca, M. 2014. New insight into the intracellular roles of class II phosphoinositide 3-kinases. Biochemical Society. Transactions. 42 (5): pp. 1378-1382.
    Source Title
    Biochemical Society. Transactions
    DOI
    10.1042/BST20140140
    ISSN
    0300-5127
    URI
    http://hdl.handle.net/20.500.11937/36636
    Collection
    • Curtin Research Publications
    Abstract

    In the last few years, an increased attention to class II isoforms of phosphoinositide 3-kinase (PI3K) has emerged, mainly fuelled by evidence suggesting a distinct non-redundant role for these enzymes compared with other PI3Ks. Despite this renewed interest, many questions remain on the specific functions regulated by these isoforms and their mechanism of activation and action. In the present review, we discuss results from recent studies that have provided some answers to these questions.

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