Physical activity and risks of proximal and distal colon cancers: A systematic review and meta-analysis
MetadataShow full item record
This is a pre-copyedited, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The version of record Boyle, T. and Keegel, T. and Bull, F. and Heyworth, J. and Fritschi, L. 2012. Physical activity and risks of proximal and distal colon cancers: A systematic review and meta-analysis. Journal of the National Cancer Institute. 104 (20): pp. 1548-1561.is available online at: http://doi.org/10.1093/jnci/djs354.
Background: Although there is convincing epidemiological evidence that physical activity is associated with a reduced risk of colon cancer, it is unclear whether physical activity is differentially associated with the risks of proximal colon and distal colon cancers. We conducted a systematic review and meta-analysis to investigate this issue. Methods: MEDLINE and EMBASE were searched for English-language cohort and case–control studies that examined associations between physical activity and the risks of proximal colon and distal colon cancers. A random-effects meta-analysis was conducted to estimate the summary relative risks (RRs) for the associations between physical activity and the risks of the two cancers. All statistical tests were two-sided. Results: A total of 21 studies met the inclusion criteria. The summary relative risk of the main results from these studies indicated that the risk of proximal colon cancer was 27% lower among the most physically active people compared with the least active people (RR = 0.73, 95% confidence interval [CI] = 0.66 to 0.81). An almost identical result was found for distal colon cancer (RR = 0.74, 95% CI = 0.68 to 0.80). Conclusion: The results of this systematic review and meta-analysis suggest that physical activity is associated with a reduced risk of both proximal colon and distal colon cancers, and that the magnitude of the association does not differ by subsite. Given this finding, future research on physical activity and colon cancer should focus on other aspects of the association that remain unclear, such as whether sedentary behavior and nonaerobic physical activity are associated with the risk of colon cancer.
Showing items related by title, author, creator and subject.
Timing and intensity of recreational physical activity and the risk of subsite-specific colorectal cancerBoyle, T.; Heyworth, J.; Bull, F.; McKerracher, S.; Platell, C.; Fritschi, Lin (2012)Purpose: Although there is convincing evidence that physical activity reduces colon cancer risk, there are important questions that remain unanswered about the association. These include the timing and intensity of activity ...
Florio, Carla; Black, Lucinda; Chih, Hui Jun; Boyle, Terry (2019)Background: The incidence rate of colorectal cancer (CRC) in Australia is one of the highest in the world. A poor diet may be associated with risk of CRC. Aim: To identify dietary patterns in an Australian population and ...
Boyle, T.; Heyworth, J.; Bull, F.; Fritschi, Lin (2011)There is convincing evidence that physical activity reduces colon cancer risk. However it is unclear whether different types of activity, such as aerobic and anaerobic activity (e.g. weight training), have a different ...