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    Physical activity and risks of proximal and distal colon cancers: A systematic review and meta-analysis

    225226_225226.pdf (536.6Kb)
    Access Status
    Open access
    Authors
    Boyle, T.
    Keegel, T.
    Bull, F.
    Heyworth, J.
    Fritschi, Lin
    Date
    2012
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Boyle, T. and Keegel, T. and Bull, F. and Heyworth, J. and Fritschi, L. 2012. Physical activity and risks of proximal and distal colon cancers: A systematic review and meta-analysis. Journal of the National Cancer Institute. 104 (20): pp. 1548-1561.
    Source Title
    Journal of the National Cancer Institute
    DOI
    10.1093/jnci/djs354
    ISSN
    0027-8874
    Remarks

    This is a pre-copyedited, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The version of record Boyle, T. and Keegel, T. and Bull, F. and Heyworth, J. and Fritschi, L. 2012. Physical activity and risks of proximal and distal colon cancers: A systematic review and meta-analysis. Journal of the National Cancer Institute. 104 (20): pp. 1548-1561.is available online at: http://doi.org/10.1093/jnci/djs354.

    URI
    http://hdl.handle.net/20.500.11937/36687
    Collection
    • Curtin Research Publications
    Abstract

    Background: Although there is convincing epidemiological evidence that physical activity is associated with a reduced risk of colon cancer, it is unclear whether physical activity is differentially associated with the risks of proximal colon and distal colon cancers. We conducted a systematic review and meta-analysis to investigate this issue. Methods: MEDLINE and EMBASE were searched for English-language cohort and case–control studies that examined associations between physical activity and the risks of proximal colon and distal colon cancers. A random-effects meta-analysis was conducted to estimate the summary relative risks (RRs) for the associations between physical activity and the risks of the two cancers. All statistical tests were two-sided. Results: A total of 21 studies met the inclusion criteria. The summary relative risk of the main results from these studies indicated that the risk of proximal colon cancer was 27% lower among the most physically active people compared with the least active people (RR = 0.73, 95% confidence interval [CI] = 0.66 to 0.81). An almost identical result was found for distal colon cancer (RR = 0.74, 95% CI = 0.68 to 0.80). Conclusion: The results of this systematic review and meta-analysis suggest that physical activity is associated with a reduced risk of both proximal colon and distal colon cancers, and that the magnitude of the association does not differ by subsite. Given this finding, future research on physical activity and colon cancer should focus on other aspects of the association that remain unclear, such as whether sedentary behavior and nonaerobic physical activity are associated with the risk of colon cancer.

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