The importance of environment on respiratory genotype/phenotype relationships in the Inuit
MetadataShow full item record
Background: Genetic and environmental influences and their interactions are central to asthma pathogenesis. This study aimed to investigate the effects of different macro-environments on asthma genotype-phenotype associations in two geographically separated populations with common ancestry. Methods: To accomplish this, two unselected populations of Inuit were recruited, one living in Greenland (n = 618) and the other in Denmark (n = 739). Subjects were genotyped for CD14 C-159T, SCGB1A1 A38G, ADRB2 Arg16Gly and Gln27Glu. The resulting genetic data were analysed for relationships with asthma-related parameters including lung function, ever asthma, atopy, rhinitis and dermatitis. Results: The results showed contrasting magnitude and direction of genetic associations between the two geographically separate Inuit populations. In Greenland, the ADRB2 16Arg allele was associated with male-specific lower lung function, but in Denmark the same allele was associated with male-specific higher lung function. This allele was also associated with higher incidence of ever asthma in Denmark but not in Greenland. The SCGB1A1 38A allele was associated with lower rhinitis prevalence in Greenland but not in Denmark. Conclusions: These associations suggest that environment interacts with candidate asthma genes to modulate asthma pathogenesis in the Inuit. © 2009 John Wiley & Sons A/S.
Showing items related by title, author, creator and subject.
Single nucleotide polymorphisms of ADRB2 gene and their association with susceptibility for Plasmodium falciparum malaria and asthma in an Indian populationSaadi, A.V.; Gupta, H.; Angural, A.; Dhanya, S.; Mony, S.; Oberoi, Devesh Varun; D'Souza, S.; Sahoo, R.; Hande, M.; Gopinath, P.; Satyamoorthy, K. (2013)The essential route to blood parasitaemia in malaria, erythrocyte invasion is facilitated by activation of the G-protein coupled receptor signaling pathway mediated by the ß2-adrenoreceptor as one of the proteins on the ...
Ali, M.; Zhang, Guicheng; Thomas, W.; McLean, C.; Bizzintino, J.; Laing, I.; Martin, A.; Goldblatt, J.; Le Souëf, P.; Hayden, C. (2009): The ST2 gene is a member of the interleukin-1 receptor family and is located on chromosome 2q12, an area of the genome that has been associated with asthma. The soluble product of the ST2 gene, serum ST2 (sST2), has ...
Leukotriene pathway polymorphisms are associated with altered cysteinyl leukotriene production in children with acute asthmaBizzintino, J.; Khoo, S.; Zhang, Guicheng; Martin, A.; Rueter, K.; Geelhoed, G.; Goldblatt, J.; Laing, I.; Le Souëf, P.; Hayden, C. (2009)Cysteinyl leukotrienes (cysLTs) are pro-inflammatory mediators with increasing evidence for a role in childhood acute asthma. This study examined the influence of polymorphisms in cysLT pathway genes on urinary leukotriene ...