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    Hypoglossal nerve stimulation improves obstructive sleep apnea: 12-month outcomes

    Access Status
    Open access via publisher
    Authors
    Kezirian, E.
    Goding, G.
    Malhotra, A.
    O'Donoghue, F.
    Zammit, G.
    Wheatley, J.
    Catcheside, P.
    Smith, P.
    Schwartz, A.
    Walsh, J.
    Maddison, K.
    Claman, D.
    Huntley, T.
    Park, S.
    Campbell, M.
    Palme, C.
    Iber, C.
    Eastwood, Peter
    Hillman, D.
    Barnes, M.
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Kezirian, E. and Goding, G. and Malhotra, A. and O'Donoghue, F. and Zammit, G. and Wheatley, J. and Catcheside, P. et al. 2014. Hypoglossal nerve stimulation improves obstructive sleep apnea: 12-month outcomes. Journal of Sleep Research. 23 (1): pp. 77-83.
    Source Title
    Journal of Sleep Research
    DOI
    10.1111/jsr.12079
    ISSN
    0962-1105
    School
    School of Physiotherapy and Exercise Science
    URI
    http://hdl.handle.net/20.500.11937/36938
    Collection
    • Curtin Research Publications
    Abstract

    Reduced upper airway muscle activity during sleep is a key contributor to obstructive sleep apnea pathogenesis. Hypoglossal nerve stimulation activates upper airway dilator muscles, including the genioglossus, and has the potential to reduce obstructive sleep apnea severity. The objective of this study was to examine the safety, feasibility and efficacy of a novel hypoglossal nerve stimulation system (HGNS®; Apnex Medical, St Paul, MN, USA) in treating obstructive sleep apnea at 12 months following implantation. Thirty-one subjects (35% female, age 52.4 ± 9.4 years) with moderate to severe obstructive sleep apnea and unable to tolerate positive airway pressure underwent surgical implantation and activation of the hypoglossal nerve stimulation system in a prospective single-arm interventional trial. Primary outcomes were changes in obstructive sleep apnea severity (apnea-hypopnea index, from in-laboratory polysomnogram) and sleep-related quality of life [Functional Outcomes of Sleep Questionnaire (FOSQ)]. Hypoglossal nerve stimulation was used on 86 ± 16% of nights for 5.4 ± 1.4 h per night. There was a significant improvement (P < 0.001) from baseline to 12 months in apnea-hypopnea index (45.4 ± 17.5 to 25.3 ± 20.6 events h-1) and Functional Outcomes of Sleep Questionnaire score (14.2 ± 2.0 to 17.0 ± 2.4), as well as other polysomnogram and symptom measures. Outcomes were stable compared with 6 months following implantation. Three serious device-related adverse events occurred: an infection requiring device removal; and two stimulation lead cuff dislodgements requiring replacement. There were no significant adverse events with onset later than 6 months following implantation. Hypoglossal nerve stimulation demonstrated favourable safety, feasibility and efficacy. © 2013 European Sleep Research Society.

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    • Treating obstructive sleep apnea with hypoglossal nerve stimulation
      Eastwood, Peter; Barnes, M.; Walsh, J.; Maddison, K.; Hee, G.; Schwartz, A.; Smith, P.; Malhotra, A.; McEvoy, R.; Wheatley, J.; O'Donoghue, F.; Rochford, P.; Churchward, T.; Campbell, M.; Palme, C.; Robinson, S.; Goding, G.; Eckert, D.; Jordan, A.; Catcheside, P.; Tyler, L.; Antic, N.; Worsnop, C.; Kezirian, E.; Hillman, D. (2011)
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