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    Persistence of Inflammatory Response to Intense Exercise in Diabetic Rats

    191126_64452_ExpDiabetesRes.pdf (772.2Kb)
    Access Status
    Open access
    Authors
    Bortolon, J.
    de Almeida Silva Junior, A.
    Murata, G.
    Newsholme, Philip
    Curi, R.
    Pithon-Curi, T.
    Hatanaka, E.
    Date
    2012
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Bortolon, Jose Ricardo and de Almeida Silva Junior, Antonio Jose and Murata, Gilson Masahiro and Newsholme, Philip and Curi, Rui and Pithon-Curi, Tania Cristina and Hatanaka, Elaine. 2012. Persistence of Inflammatory Response to Intense Exercise in Diabetic Rats. Experimental Diabetes Research. 2012: Article ID 213986.
    Source Title
    Experimental Diabetes Research
    DOI
    10.1155/2012/213986
    ISSN
    1687-5214
    Remarks

    This article is published under the Open Access publishing model and distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/ . Please refer to the licence to obtain terms for any further reuse or distribution of this work.

    URI
    http://hdl.handle.net/20.500.11937/37166
    Collection
    • Curtin Research Publications
    Abstract

    In this study we evaluated the onset and resolution of inflammation in control and streptozotocin-induced diabetic rats subjected to a single session of intense exercise. The following measurements were carried out prior to, immediately after, and 2 and 24 hours after exercise: plasma levels of proinflammatory cytokines (TNF-α, IL-1β, IL-6, CINC-2α/β, MIP-3α, and IL-6), immunoglobulins (IgA and IgM), acute phase proteins (CRP and C3), and creatine kinase (CK) activity. We also examined the occurrence of macrophage death by measurements of macrophages necrosis (loss of membrane integrity) and DNA fragmentation. An increase was observed in the concentration of IL-1β (3.3-fold) and TNF-α (2.0-fold) and in the proportion of necrotic macrophages (4.5-fold) in diabetic rats 24 hours after exercise, while the control group showed basal measurements. Twenty-four hours after the exercise, serum CK activity was elevated in diabetic rats but not in control animals. We concluded that lesion and inflammations resulting from intense exercise were greater and lasted longer in diabetic animals than in nondiabetic control rats.

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