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    Detection of liver injury in IBD using Transient Elastography

    199443_199443.pdf (257.3Kb)
    Access Status
    Open access
    Authors
    Thin, L.
    Lawrance, I.
    Spilsbury, Katrina
    Kava, J.
    Olynyk, John
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Thin, L. and Lawrance, I. and Spilsbury, K. and Kava, J. and Olynyk, J. 2014. Detection of liver injury in IBD using Transient Elastography. Journal of Crohn's and Colitis. 8 (7): pp. 671-677.
    Source Title
    Journal of Crohn's and Colitis
    DOI
    10.1016/j.crohns.2013.12.006
    ISSN
    1873-9946
    Remarks

    This is the author’s version of a work that was accepted for publication in the Journal of Crohn's and Colitis. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in the Journal of Crohn's and Colitis, Volume 8, Issue 7, 1 July 2014, Pages 671–677. http://doi.org/10.1016/j.crohns.2013.12.006

    URI
    http://hdl.handle.net/20.500.11937/37600
    Collection
    • Curtin Research Publications
    Abstract

    Background: Up to 5% of inflammatory bowel disease (IBD) patients are thought to have clinically significant liver disease due to multifactorial causes, however, this figure may be an underestimate due to reliance on abnormal liver tests (LTs) and/or liver biopsies. Aims: Our aim was to evaluate the prevalence of clinically significant liver disease in IBD patients as defined by an increased liver stiffness measurement (LS) ≥ 8 kPa using transient elastography (TE). Methods: 110 IBD patients, and 55 non-IBD control subjects, had their LS recorded using FibroScan® (EchoSense, Paris, France) by a single blinded operator trained in TE. Results: 71 Crohn's disease and 39 ulcerative colitis subjects were included. All demographic variables were similar between the IBD and control groups apart from a significantly higher proportion of IBD patients who smoked (17.3% vs 3.6%, P = 0.013). Seven IBD patients (6.4%) had an LS over 8 kPa and 3 had persistently elevated LS 6 months later. One patient had compensated cirrhosis. No significant differences in overall LS were observed between the IBD and control groups. Increased BMI and age, however, were independently associated with higher LS in the IBD but not in the control group (P < 0.001 and 0.010 respectively). Conclusion: Using TE, the prevalence of clinically significant liver disease in IBD patients is low. The association of increased BMI and age with increased LS in IBD suggests fatty liver disease being the prevailing aetiology in these patients.

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