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dc.contributor.authorZhang, Guicheng
dc.contributor.authorCandelaria, P.
dc.contributor.authorMäkelä, J.
dc.contributor.authorKhoo, S.
dc.contributor.authorHayden, M.
dc.contributor.authorvon Hertzen, L.
dc.contributor.authorLaatikainen, T.
dc.contributor.authorVartiainen, E.
dc.contributor.authorGoldblatt, J.
dc.contributor.authorHaahtela, T.
dc.contributor.authorLesouëf, N.
dc.date.accessioned2017-01-30T14:06:28Z
dc.date.available2017-01-30T14:06:28Z
dc.date.created2015-10-29T04:08:49Z
dc.date.issued2011
dc.identifier.citationZhang, G. and Candelaria, P. and Mäkelä, J. and Khoo, S. and Hayden, M. and von Hertzen, L. and Laatikainen, T. et al. 2011. Disparity of innate immunity-related gene effects on asthma and allergy on Karelia. Pediatric Allergy and Immunology. 22 (6): pp. 621-630.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/37692
dc.identifier.doi10.1111/j.1399-3038.2011.01186.x
dc.description.abstract

Background: We investigated the interactive effects of 11 innate immunity-related genes (IL10, IL12b, IL8, TLR2, TLR4, CD14, IFNGR, CC16, IFNg, CMA1, and TGFB) and four IgE response genes (IL4, IL13, IL4RA, and STAT6) with 'Western' or 'Eastern' environments/lifestyles on asthma and allergy in Karelian children. Methods: Karelian children (412 Finnish and 446 Russian) were recruited and assessed for a range of allergic conditions, with 24 single-nucleotide polymorphisms genotyped in 15 genes. Results: The genotype-phenotype relationships differed in Finnish and Russian Karelian children. The interaction between polymorphisms and the variable representing 'Western' and 'Eastern' environments/lifestyles was significant for IL10-1082 (p=0.0083) on current rhinitis, IL12b 6408 on current conjunctivitis (p=0.016) and atopy (p=0.034), IL8 781 on atopic eczema (p=0.0096), CD14 -550 on current rhinitis (p=0.022), IFNgR1 -56 on atopic eczema(p=0.038), and STAT6 2964 on current itchy rash (p=0.037) and total serum IgE (p=0.042). In addition, the G allele of IL13 130 was associated with a lower level of total serum IgE in Finnish (p=0.003) and Russian (p=0.01) children and overall (pooling the two populations together, p=0.00006). After adjusting for multiple tests, the association between IL13 130 and IgE and the interactive effects of IL10-1082 on current rhinitis and IL8 781 on atopic eczema were significant by controlling a false-positive rate of 0.05 and 0.10, respectively. Conclusions: Living in an Eastern vs. Western environment was associated with a different genetic profile associated with asthma and allergy in the Karelian populations. © 2011 John Wiley & Sons A/S.

dc.titleDisparity of innate immunity-related gene effects on asthma and allergy on Karelia
dc.typeJournal Article
dcterms.source.volume22
dcterms.source.number6
dcterms.source.startPage621
dcterms.source.endPage630
dcterms.source.issn0905-6157
dcterms.source.titlePediatric Allergy and Immunology
curtin.departmentSchool of Public Health
curtin.accessStatusFulltext not available


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