In older men, higher plasma testosterone or dihydrotestosterone is an independent predictor for reduced incidence of stroke but not myocardial infarction
MetadataShow full item record
Context: Older men have lower T levels, but whether differences in circulating T or its metabolites dihydrotestosterone (DHT) or estradiol (E2) contribute to cardiovascular disease remains controversial. Objective: We tested the hypothesis that plasma T, DHT, and E2 are differentially associated with the incidence of myocardial infarction (MI) and stroke in older men. Participants and Methods: Plasma total T, DHT, and E2 were assayed using liquid chromatography-mass spectrometry in early-morning samples from 3690 community-dwelling men aged 70–89 years. Outcomes of the first hospital admission or death due to MI or stroke were ascertained by data linkage. Results: Mean follow-up was 6.6 years. Incident MI occurred in 344, stroke in 300, and neither in 3046 men. In a multivariate analysis adjusting for age and other risk factors, T, DHT, and E2 were not associated with incident MI [fully adjusted hazard ratio (HR) for T in quartile (Q) 4 vs Q1: 0.92, 95% confidence interval (CI) 0.66–1.28; DHT: 0.83, 95% CI 0.59–1.15; E2: 0.84, 95% CI 0.62–1.15]. Higher T or DHT was associated with a lower incidence of stroke (T: Q4: Q1 fully adjusted HR 0.56, 95% CI 0.39–0.81, P = .002; DHT: 0.57, 95% CI 0.40–0.81, P = .002). E2 was not associated with stroke (HR 0.76, 95% CI 0.54–1.08, P = .123). Conclusions: Higher plasma T or DHT is a biomarker for reduced risk of stroke but not MI. Androgen exposure may influence outcomes after rather than the incidence of MI, whereas androgens but not E2 are independent predictors of stroke risk. Randomized clinical trials are needed to clarify the impact of modifying T or DHT on the risk of stroke in aging men.
Showing items related by title, author, creator and subject.
Troponin T, N-terminal pro-B-type natriuretic peptide, and incidence of stroke: The atherosclerosis risk in communities studyFolsom, A.; Nambi, V.; Bell, E.; Oluleye, O.; Gottesman, R.; Lutsey, P.; Huxley, Rachel; Ballantyne, C. (2013)Background and Purpose-Increased levels of plasma troponins and natriuretic peptides are associated with increased risk of cardiovascular disease, but only limited information exists on these biomarkers and stroke occurrence. ...
Validity of self-reported versus hospital-coded diagnosis of stroke: A cross-sectional and longitudinal studyJamrozik, E.; Hyde, Z.; Alfonso, Helman; Flicker, L.; Almeida, O.; Yeap, B.; Norman, P.; Hankey, G.; Jamrozik, K. (2014)Background: Population-based studies, as well as clinicians, often rely on self-report and hospital records to obtain a history of stroke. This study aimed to compare the validity of the diagnosis of stroke by self-report ...
A comparative analysis of risk factors for stroke in blacks and whites: The Atherosclerosis Risk in Communities studyHuxley, Rachel; Bell, E.; Lutsey, P.; Bushnell, C.; Shahar, E.; Rosamond, W.; Gottesman, R.; Folsom, A. (2014)© 2013 Taylor and Francis. Objective. Previous studies have speculated that the higher stroke incidence rate (IR) in blacks compared with whites may be due, in part, to stroke risk factors exerting a more adverse effect ...