Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    HIV neuropathy risk factors and symptom characterization in stavudine-exposed South Africans

    Access Status
    Fulltext not available
    Authors
    Wadley, A.
    Cherry, C.
    Price, Patricia
    Kamerman, P.
    Date
    2011
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Wadley, A. and Cherry, C. and Price, P. and Kamerman, P. 2011. HIV neuropathy risk factors and symptom characterization in stavudine-exposed South Africans. Journal of Pain and Symptom Management. 41 (4): pp. 700-706.
    Source Title
    Journal of Pain and Symptom Management
    DOI
    10.1016/j.jpainsymman.2010.07.006
    ISSN
    0885-3924
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/37910
    Collection
    • Curtin Research Publications
    Abstract

    Context: HIV-associated sensory neuropathy (HIV-SN) is a frequent complication of both HIV and neurotoxic antiretroviral medications such as stavudine. Objectives: To determine the prevalence, risk factors, and clinical characteristics of symptomatic HIV-SN in a Black South African cohort of patients exposed to stavudine. Methods: HIV-positive Black South Africans (n = 395) who had received stavudine for at least six months were recruited at the Virology Clinic of the Charlotte Maxeke Academic Johannesburg Hospital, South Africa, and screened for neuropathy using the AIDS Clinical Trials Group neuropathy screening tool. HIV-SN was defined as present if the patient had both symptoms and signs of peripheral neuropathy. If present, the distribution and intensity of symptoms were recorded. In addition, anthropomorphic, demographic, and clinical information were recorded and analyzed as risk factors. Results: The prevalence of symptomatic HIV-SN was 57% (226 of 395). Increasing age and height were independently associated with the development of SN among patients who had used stavudine. Pain was the primary symptom reported by participants with HIV-SN (76%, 172 of 226), followed by numbness (48%, 108 of 226), and pins and needles (46%, 105 of 226). About three-quarters of participants rated their symptoms as being of moderate to severe intensity. Symptoms were always present in the feet and only 23% experienced symptoms proximal to the feet. Conclusion: HIV-SN was common in this population and frequently associated with moderate to severe pain in the feet. HIV-SN was significantly associated with increasing age and height, factors that could be measured at no added cost prior to stavudine prescription, allowing higher risk patients to be offered priority access to nonneurotoxic drugs. © 2011 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.

    Related items

    Showing items related by title, author, creator and subject.

    • Neuropathic pain in HIV patients receiving ART without stavudine in an Indonesia Referral Hospital
      Octaviana, F.; Safri, A.; Setiawan, D.; Estiasari, R.; Imran, D.; Ranakusuma, T.; Price, Patricia (2019)
      Lower limb neuropathic pain in HIV patients is a common manifestation of sensory neuropathy (HIV-SN), but can be seen in patients who do not meet standard definitions of HIV-SN. The drug stavudine is a risk factor for ...
    • Age and height predict neuropathy risk in patients with HIV prescribed stavudine
      Cherry, C.; Affandi, J.; Imran, D.; Yunihastuti, E.; Smyth, K.; Vanar, S.; Kamarulzaman, A.; Price, Patricia (2009)
      OBJECTIVE: Sensory neuropathy is a common problem in HIV-infected patients and is the dose-limiting toxicity of stavudine. Affordable methods of predicting neuropathy risk are needed to guide prescribing in countries where ...
    • Ex-vivo expression of chemokine receptors on cells surrounding cutaneous nerves in patients with HIV-Associated sensory neuropathy
      Mountford, Jenjira; Octaviana, F.; Estiasari, R.; Setiawan, D.; Ariyanto, I.; Lee, Silvia; Gaff, Jessica; Chew, C.; Jackaman, Connie; Kamerman, Peter; Cherry, C.; Price, Patricia (2018)
      Objective: HIV-Associated sensory neuropathy (HIV-SN) remains common in HIV+ individuals receiving antiretroviral therapy (ART), even though neurotoxic antiretroviral drugs (e.g. stavudine) have been phased out of use. ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.