Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Atrial fibrillation and cognitive decline-the role of subclinical cerebral infarcts: The atherosclerosis risk in communities study

    Access Status
    Open access via publisher
    Authors
    Chen, L.
    Lopez, F.
    Gottesman, R.
    Huxley, Rachel
    Agarwal, S.
    Loehr, L.
    Mosley, T.
    Alonso, A.
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Chen, L. and Lopez, F. and Gottesman, R. and Huxley, R. and Agarwal, S. and Loehr, L. and Mosley, T. et al. 2014. Atrial fibrillation and cognitive decline-the role of subclinical cerebral infarcts: The atherosclerosis risk in communities study. Stroke. 45 (9): pp. 2568-2574.
    Source Title
    Stroke
    DOI
    10.1161/STROKEAHA.114.005243
    ISSN
    0039-2499
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/37949
    Collection
    • Curtin Research Publications
    Abstract

    BACKGROUND AND PURPOSE: The mechanism underlying the association of atrial fibrillation (AF) with cognitive decline in stroke-free individuals is unclear. We examined the association of incident AF with cognitive decline in stroke-free individuals, stratified by subclinical cerebral infarcts (SCIs) on brain MRI scans. METHODS: We analyzed data from 935 stroke-free participants (mean age±SD, 61.5±4.3 years; 62% women; and 51% black) from 1993 to 1995 through 2004 to2006 in the Atherosclerosis Risk in Communities Study, a biracial community-based prospective cohort study. Cognitive testing (including the digit symbol substitution and the word fluency tests) was performed in 1993 to 1995, 1996 to 1998, and 2004 to 2006 and brain MRI scans in 1993 to 1995 and 2004 to 2006. RESULTS: During follow-up, there were 48 incident AF events. Incident AF was associated with greater annual average rate of decline in digit symbol substitution (-0.77; 95% confidence interval, -1.55 to 0.01; P=0.054) and word fluency (-0.80; 95% confidence interval, -1.60 to -0.01; P=0.048). Among participants without SCIs on brain MRI scans, incident AF was not associated with cognitive decline. In contrast, incident AF was associated with greater annual average rate of decline in word fluency (-2.65; 95% confidence interval, -4.26 to -1.03; P=0.002) among participants with prevalent SCIs in 1993 to 1995. Among participants who developed SCIs during follow-up, incident AF was associated with a greater annual average rate of decline in digit symbol substitution (-1.51; 95% confidence interval, -3.02 to -0.01; P=0.049). CONCLUSIONS: The association of incident AF with cognitive decline in stroke-free individuals can be explained by the presence or development of SCIs, raising the possibility of anticoagulation as a strategy to prevent cognitive decline in AF.

    Related items

    Showing items related by title, author, creator and subject.

    • Randomized placebo-controlled trial of the effects of aspirin on dementia and cognitive decline.
      Ryan, Joanne; Storey, Elsdon; Murray, Anne M; Woods, Robyn L; Wolfe, Rory; Reid, Christopher ; Nelson, Mark R; Chong, Trevor TJ; Williamson, Jeff D; Ward, Stephanie A; Lockery, Jessica E; Orchard, Suzanne G; Trevaks, Ruth; Kirpach, Brenda; Newman, Anne B; Ernst, Michael E; McNeil, John J; Shah, Raj C; ASPREE Investigator Group (2020)
      OBJECTIVE: To determine the effect of low-dose aspirin vs placebo on incident all-cause dementia, incident Alzheimer disease (AD), mild cognitive impairment (MCI), and cognitive decline in older individuals. METHODS: ...
    • Higher free thyroxine levels predict increased incidence of dementia in older men: The health in men study
      Yeap, B.; Alfonso, Helman; Chubb, S.; Puri, G.; Hankey, G.; Flicker, L.; Almeida, O. (2012)
      Context: Both hypothyroidism and subclinical hyperthyroidism hinder cognitive function. Objective: We aimed to determine whether more subtle alterations of thyroid hormone levels predict increased incidence of dementia ...
    • Erectile dysfunction and later cardiovascular disease in men with type 2 diabetes: Prospective cohort study based on the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation) trial
      Batty, G.; Li, Q.; Czernichow, S.; Neal, B.; Zoungas, S.; Huxley, Rachel; Patel, A.; De Galan, B.; Woodward, M.; Hamet, P.; Harrap, S.; Poulter, N.; Chalmers, J. (2010)
      Objectives The aim of this study was to examine the relationship between erectile problems in men and cardiovascular disease (CVD) mortality. Background Although there are plausible mechanisms linking erectile dysfunction ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.